Objective:To discusses the development of the follicle stimulating mechanism by observing Yangjing Zhongyu decoction reducing insulin resistance induced by excess androgen in follicle.Method: ①Follicles from porcine ovary were isolated and cultured in vitro.The follicles were induced by excess androgen for 48 h.Then the follicle glucose intake and glucose content were measured in culture solution.②The protein expression of insulin receptor substrate-1（IRS-1） and glucose transporter 4（GLUT4）and glucose content were detect in culture solution of each group.Result: After being treated by excess androgen for 48 h

follicle glucose intake was decreased about 39.56%（P<0.01）

the glucose content in culture solution was increased for about 29.08%（P<0.01）.The levels of IRS-1 and GLUT4 protein expression was decreased about 74% and 94.56% in follicles induced by excess androgen（P<0.01

P<0.01）.However

the protein expression of IRS-1 and GlUT4 was increased 2 times and 5 times（P<0.01）

the glucose content in culture solution was decreased for about 33.6%（P<0.001）after treated with Yangjing Zhongyu decoction.Conclusion: The mechanism of excess androgen can induce in sulin resistance and Yangjing Zhongyu decoction reduce insulin resistance in follicle which may be related to the levels of IRS-1 and GLUT4 protein expression.