Objective:To investigate the effect of polysaccharide from Niuxin persimmon leaf on diabetic mice induced by streptozotocin.Method: Diabetics in fifty mice was induced by Streptozotocin（STZ） peritoneal injection with a dose of 150 mg · kg-1（the normal control group was excluded）.Being evidenced by fasting blood-glucose（FBG） for diabetic establishment

then the mice were randomly divided into 5 groups

with 10 mice in each group: model group

dimethyldiguanide group（0.32 g · kg-1）

low-

medium-and high-dosage groups of Niuxin persimmon leaf polysaccharide（0.4

0.6

1.2 g · kg-1）.The mice in the normal and model control groups were given same volume of normal saline.The drugs were given to mice daily for 15 consecutive days.At the end of the 15th day

the rats were fasted for 12 h before drug administration

then at 1 h after drug administration the blood samples were collected via evulseing the eyes

and centrifuged to obtain serum for test.Glucose oxidase（GOD） and radioimmunoassay（RIA） were used to examine the index of glycemia and insulin for fasting blood glucose（FBG）

fasting insulin（FNS）

insulin sensitivity index（ISI）

insulin resistance（IR）.Triglyceride（TG）

total cholesterol（TC）

low-density lipoprotein cholesterol（LDL-C）.high-density lipoprotein cholesterol（HDL-C） were also tested.Result: Comparing to the model control group

the treatment could effectively restore the condition of diabetic mice induced by STZ

Niuxin persimmon polysaccharide could significantly reduce the levels of blood sugar and blood lipid

the difference was statistically significant（P<0.05 and P<0.01）

and appreciably recover insulin levels

the difference was statistically significant（P<0.05 and P<0.01）.Conclusion: Polysaccharide from Niuxin persimmon leaf demonstrates hypoglycemic and hypolipidemic effects through the mechanisms that may be associated with improving diabetic mice antioxidant capacity and restoring islet function.