Objective:To investigate the depressant effect of Astragali injection on insulin resistance and oxidative stress in rats treated by high-fructose diet.Method: SD rats were randomly divided into model group

Astragali injection high

low dose（5

2.5 g · kg-1

equivalent to the amount of crude drug

ip） groups

rosiglitazone（3 mg · kg-1

ig） group after fed with high-fructose forage for 4 weeks and were given high-fructose forage for another 4 weeks.The rats in the normal group were given ordinary forage.The body weight

fasting blood glucose

plasma insulin

insulin sensitivity index

oxidative stress indicators were determined.Result: There was no significant difference between model group’s body weight and normal group’s body weight;the fasting blood glucose

plasma insulin levels

insulin resistance index

（MDA） content were markedly higher than normal group（P<0.05）;catalase（CAT）

superoxide dismutase（SOD）

glutathione peroxidase（GSH-Px） activities were significantly lower than those in normal group（P<0.05）.Compared with the model group

the fasting blood glucose

plasma insulin levels

insulin resistance index

malonaldehyde MDA content decreased

while CAT

SOD

GSH-Px activities increased in the Astragali injection groups and rosiglitazone group.There was significant difference between high dose group and model group（P<0.05）.Conclusion: Astragali injection can release insulin resistance and oxidative stress induced by high-fructose diet.