Objective:To investigate different doses of ’Aconiti Lateralis Radix Praeparatat’ in regulating ventricular remodeling

neuroendocrine

hemodynamic in chronic heart failure（CHF） rats.Method: A rat model of CHF was established by ligating left anterior descending coronary artery way

ninety Sprague-Dawley（SD） rats were randomly assigned into sham-operation group

model group

captopril-control group

decoction of Aconiti Lateralis Radix Praeparata low（4.5 g · kg-1）

high（9 g · kg-1） dose group

drug intervention was started on 28th day after operation

corresponding drugs was given to each treatment group by gavage for 4 weeks.Meanwhile

the same volume of physiological saline was given to the model group and the sham-operation group by gavage once a day for 4 weeks.The hemodynamic

neuroendocrine

ventricular remodeling data were detect by normal way.Result: Fifty rats were survived after operation and observation of hemodynamic data

left ventricular remodeling and angiotension II in high dose group were greatly deteriorated than model group

captopril group and low dose group（P<0.05）.Data of hemodynamic were significantly decreased in high dose group（P<0.05）.Angiotension II in captopril and low dose group were lower than model group（P<0.05）.Conclusion: High dose usage of Aconiti Lateralis Radix Praeparata may harm hemodynamic

neuoendocrine and ventricular remodeling of CHF rats.Like captpril

low dose usage of ’prepared aconite root’ can moderate neuroendocrine of CHF rats.