Objective:The influences of Magnoliae Officinalis Cortex on stomach dynamic and ulcer in ratsbefore and after its diaphoretic processing were investigated.Method: The gastric motility disorder in SD rats was established by injecting L-Arg intraperitoneally for five days

then the rats were given the extract of Magnoliae（Magnoliae Officinalis Cortex 10 g · kg-1） by intragastric administration

the extract of diaphoretic Magnoliae（diaphoretic Magnoliae Officinalis Cortex 10 g · kg-1） was gived by intragastric administration

cisapride（0.004 g · kg-1） by intraperitoneal injection

respectively

gastric residual rate was determined

then improving effect by Magnolia Officinalis Cortex before and after its diaphoretic processing was observed.Kunming mice were given 0.35 mL 0.6 mol · L-1 hydrochloric acid by ig

HCI-induced gastric ulcer was established.mice were given 10 g · kg-1 indomethacin by ip and 0.15 mL 50% ethanol by ig

indomethacin-ethanol-ulcer was established

and antiulcer effect between pre-and post treatment of diaphoretic Magnoliae Officinalis Cortex was observed by giving the extract of Magnoliae Officinalis Cortex（Magnoliae Officinalis Cortex 10 g · kg-1）

the extract of diaphoretic Magnoliae Officinalis Cortex（diaphoretic Magnoliae Officinalis Cortex 10 g · kg-1）

0.04 g·kg-1 ranitidine hydrochloride for continuous 3 d.Result: Gastrointestinal motility in rats injected by L-Arg intraperitoneally was slowed down

plasma motilin was reduced.The extract of Magnoliae Officinalis Cortex

the extract of diaphoretic Magnoliae Officinalis Cortex could effectively inhibit the decrease in Gastrointestinal motility（P<0.05） and plasma motilin（P<0.05）

and there was a significant difference between the diaphoretic Magnoliae Officinalis Cortex group and the Magnoliae Officinalis Cortex group

and the diaphoretic Magnoliae Officinalis Cortex groupand the group cisapride（P<0.05）.Gastric residual rate in the extract of Magnoliae Officinalis Cortexand the extract of diaphoretic Magnoliae Officinalis Cortex group

cisapride was（70.2±14.1）%

（61.5±12.8）%

（71.3±12.4）% respectively;plasma motilin was（84.8±11.6）

（92.9±11.7）

（85.4±12.1）nmol · L-1.Both Magnoliae Officinalis Cortex and diaphoretic Magnoliae Officinalis Cortex could reduce the index of HCl-ulcer and indomethacin-ethanol-ulcer（P<0.01）

and the index of HCl-ulcer and indomethacin-ethanol-ulcer of diaphoretic Magnoliae Officinalis Cortex was smaller to that of Magnoliae Officinalis Cortex（P<0.01）.The index of HCl-ulcer in the extract of Magnoliae Officinalis Cortex

the extract of diaphoretic Magnoliae Officinalis Cortex and ranitidine hydrochloride groups was（36.8±10.4）

（29.5±8.2）

（17.5±10.1）mm respectively;indomethacin-ethanol-ulcer were（45.4±11.7）

（33.8±11.0）

（20.3±4.9）mm.Conclusion: Diaphoretic Magnoliae Officinalis Cortex is better than Magnoliae Officinalis Cortex on improving the gastric motility disorder and antiulcer effect

so processing technology of diaphoretic Magnolia Officinalis Cortex is necessary.