桃仁提取物对痴呆模型小鼠脑组织SOD,GSH-Px活性和MDA含量的影响

方美善; 张红英

doi:10.13422/j.cnki.syfjx.2012.16.048

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桃仁提取物对痴呆模型小鼠脑组织SOD,GSH-Px活性和MDA含量的影响

药理 | 更新时间：2024-09-23

- 桃仁提取物对痴呆模型小鼠脑组织SOD,GSH-Px活性和MDA含量的影响
- Effects of Extract from Semen Persicae on SOD,GSH-Px Activity and MDA Contents of Brain Tissue in Mice Dementia Model
- 中国实验方剂学杂志 2012年18卷第16期页码：236-238
- 作者机构：
  
  1. 延边大学附属医院神经内科
  2. 延边大学医学院机能学实验中心
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.16.048
  中图分类号： R285
- 纸质出版日期：2012
- 稿件说明：
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[1]方美善,张红英.桃仁提取物对痴呆模型小鼠脑组织SOD,GSH-Px活性和MDA含量的影响[J].中国实验方剂学杂志,2012,18(16):236-238.

FANG Mei-shan1, ZHANG Hong-ying2. Effects of Extract from Semen Persicae on SOD,GSH-Px Activity and MDA Contents of Brain Tissue in Mice Dementia Model[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(16): 236-238.
[1]方美善,张红英.桃仁提取物对痴呆模型小鼠脑组织SOD,GSH-Px活性和MDA含量的影响[J].中国实验方剂学杂志,2012,18(16):236-238. DOI： 10.13422/j.cnki.syfjx.2012.16.048.

FANG Mei-shan1, ZHANG Hong-ying2. Effects of Extract from Semen Persicae on SOD,GSH-Px Activity and MDA Contents of Brain Tissue in Mice Dementia Model[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(16): 236-238. DOI： 10.13422/j.cnki.syfjx.2012.16.048.

摘要

目的:研究桃仁乙醇提取物对三氯化铝（AlCl3）致痴呆模型小鼠脑组织超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）活性和丙二醛（MDA）含量的影响。方法:采用ig给小鼠AlCl3的方法复制痴呆模型。按小鼠体重随机分为正常组、模型组、桃仁乙醇提取物高、中、低剂量（2.4

1.2

0.620g.kg-1）组

每组10只。造模同时开始给药

连续灌胃4020d后处死小鼠

取脑组织

检测脑组织SOD

GSH-Px和MDA的含量。结果:与正常组比较

模型组可以显著降低小鼠脑组织SOD

GSH-Px活性

显著增加MDA含量;与模型组比较

桃仁乙醇提取物组可以显著增加小鼠脑组织SOD

GSH-Px活性

显著降低MDA含量（P<0.01

P<0.05）。结论:桃仁乙醇提取物具有清除氧自由基和抗氧化功能

桃仁乙醇提取物可能通过提高SOD

GSH-Px活性

降低MDA含量来改善痴呆。

Abstract

Objective:To study the effects of ethanol extract from Semen Persicae on superoxide dismutase（SOD）

glutathione peroxidase（GSH-Px） activity and malondialdehyde（MDA） contents of brain tissue in the mice dementia model b induced by AlCl3.Method: To establish the mice dementiamodel of AlCl3was ig given.They were divided into 5 groups: the control group

the model group and the doses groups of high

middle and low extracts（2.4

1.2

0.6 g · kg-1） from Semen Persicae randomly

10 of each group.And modeling mice were ig given corresponding drugs after 40 d continuously

then they were sacrificed.SOD

GSH-Px activity and MDA contents of brain tissue were measured in dementia mice.Result: In the model group activity of SOD and GSH-Px of brain tissue were decreased

the contents of MDA of brain tissue was increased compared with the control group.The ethanol extracts groups from Semen Persicae could obviously increase activity of SOD and GSH-Px of brain tissue and decrease the contents（P<0.01

P<0.05）of MDA of brain tissue compared with the model group.Conclusion: The ethanol extract from Semen Persicae has scavenging oxygen free radicals and anti-oxidation effects.

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