Objective:To investigate the protecting effect of Xinshu dicoction against arrhythmia and ischemia myocardial in animal model.Method: Hundred mice were divided into Xinshu dicoction high

middle and low dose group（1.7

0.85

0.42 g · kg-1）

model group（0.2 mL water）

Guanxin Danshen capsules（0.35 g ·kg-1） group at random.After continuous oral administration for 14 d

arrhythmia animal model induced by chloroform in mice was copied to observe incidence of ventricular fibrillation（VF）.Fifty rats were randomly divided 5 groups: Xinshu dicoction high

middle and low dose group（1.18

0.59

0.29 g · kg-1）

model group（2 mL water）

Guanxin Danshen capsules group（0.24 g · kg-1）.Oral administration lasted 14 days

isoproterenol-induced myocardial ischemia model was esyablished in rats to observed protective effect of Xinshu dicoction.Total 60 rats were divided into 6 groups and given drugs for 14 d in the same way as mentioned above.In the 12 d and isoproterenol（ISO） was used to establish myocardial ischemia model in rats twice.This was aimed to watch the protection of Xinshu dicoction on myocardial ischemia.Result: Xinshu dicoction could reduce the incidence of VF caused by chloroform to 25% in mice

could increase dosage of aconitine when ventricular prematoure（VP）

ventricular tachycardia（VT）

ventricular fibrillation（VF） happened in rats to 19.7

23.7

32.6 μg · kg-1.Xinshu dicoction could reduce wave amplitude of T wave and the level of creatine kinase（CK） and aspartate aminotransiferase（AST） in serum of ischemia myocardial rats to 2 572.9

111.3 U · L-1.Conclusion: Xinshu dicoction has a protective effect on arrhythmia and ischemia myocardial.