Objective:Experiments were carried on to identify the pharmacodynamic differences between aqueous extracts and Ethanol Extractes from Fritillaria unibracteata and F.thunbergii.Method: The antitussive effects were investigated through observng the cough time and 50% effect time（ET50）induced by ammonium hydroxide in mice

the counts of cough induced by critic acid in guinea pigs.The expectorant activity was studied by testing the amount of phlegm secreted in mice and rats.The antiasthma effects were studied by the asthma time induced by acetylcholine chloride and histamine phosphate in guinea pigs.The dose of 5 Fritillarias in the antitussive experiment was 5 g · kg-1 in mice and 1.5 g · kg-1 in guinea pig.The codeine phosphate saved as positive control on the dose of 25 mg · kg-1 in mice and 20 mg · kg-1 in guinea pigs.The dose offritillarias was 2 g · kg-1 in mice and 1 g · kg-1 in rat

the ammonium chloride saved as positive control on the dose of 1 g · kg-1.The dose of 5 fritillarias was 1.5 g · kg-1 and the salbutamol sulfate saved as positive control on the dose of 4.5 mg · kg-1.Result: F.unibracteata powder had conspicuous effect on elimilating cough sputum and asthma

the difference between was significant P<0.05.The ethanol extracts of F.unibracteata had similar eliminating phlegm activity

the difference of ET50 and cough times between the two groups was significant P<0.05.The aqueous extractives and the composition of aqueous and ethanol extracts of F.unibracteata had similar eliminating cough activity

the difference was significant P<0.05.Conclusion: Aqueous extracts of F.unibracteata may be the expectorant effective constituent and the ethanol extractis of F.unibracteata may be the anti-tussive effective constituent.