Objective:To study effect of different excipients on quality parameters of Jianwei Xiaoshi tablet

in order to provide a scientific basis on process optimization of actual production.Method: Four kinds of Jianwei Xiaoshi tablet were developed by wet granulation and tableting with different accessories

cumulative dissolution was determined by small glass method

similar factor of dissolution curve was fitted

model of dissolution mechanism was fitted.Result: In 4 kinds of different Jianwei Xiaoshi tablet

there were significant differences between sample Ⅰand Ⅱ

Ⅲ

Ⅳ of hesperidin dissolution curve

there are no significant differences among Ⅱ

Ⅲ and Ⅳ;dissolution of hesperidin was fastest of sample Ⅱ

and cumulative dissolution was highest;Dissolution behavior of hesperidin was closest to the kinetic equation.Conclusion: The best accessories of Jianwei Xiaoshi tablet was dextrin

sucrose

magnesium stearate and so on.