丹黄凝胶体外释放和经皮渗透特性考察

程建明; 陈新民; 彭稳稳; 李俊松; 李文

doi:10.13422/j.cnki.syfjx.2012.18.025

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丹黄凝胶体外释放和经皮渗透特性考察

制剂与工艺 | 更新时间：2024-09-23

- 丹黄凝胶体外释放和经皮渗透特性考察
- Investigation of in vitro Release and Transdermal Permeability Characteristics of Danhuang Gel
- 中国实验方剂学杂志 2012年18卷第18期页码：24-26
- 作者机构：
  
  1. 南京中医药大学
  2. 江苏省南京市中医院
- 作者简介：
- 基金信息：
  
  江苏省中医药局科技项目（LB09081）
- DOI：10.13422/j.cnki.syfjx.2012.18.025
  中图分类号： R283
- 纸质出版日期：2012
- 稿件说明：
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[1]程建明,陈新民,彭稳稳,李俊松,李文.丹黄凝胶体外释放和经皮渗透特性考察[J].中国实验方剂学杂志,2012,18(18):24-26.

CHENG Jian-ming1, CHEN Xin-min1, PENG Wen-wen1, et al. Investigation of in vitro Release and Transdermal Permeability Characteristics of Danhuang Gel[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(18): 24-26.
[1]程建明,陈新民,彭稳稳,李俊松,李文.丹黄凝胶体外释放和经皮渗透特性考察[J].中国实验方剂学杂志,2012,18(18):24-26. DOI： 10.13422/j.cnki.syfjx.2012.18.025.

CHENG Jian-ming1, CHEN Xin-min1, PENG Wen-wen1, et al. Investigation of in vitro Release and Transdermal Permeability Characteristics of Danhuang Gel[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(18): 24-26. DOI： 10.13422/j.cnki.syfjx.2012.18.025.

摘要

目的:研究丹黄凝胶体外释药特性和体外经皮渗透性。方法:采用改良Franz扩散池

以大黄酚、小檗碱为评价指标

运用动力学模型描述指标成分在体外的释药规律和经皮渗透规律。结果:大黄酚以零级动力释放模型拟合优度最好

小檗碱以Ritger-Peppas模型拟合优度最好;大黄酚和小檗碱在体外皮肤均以一级动力学渗透吸收;大黄酚、小檗碱体外释药特性与经皮渗透性的相关方程分别为Y=0.468 7X+4.972 2（r=0.966 4）

Y=0.666 9X+2.487 4（r=0.974 0）

体外释放速率均>体外经皮速率。结论:大黄酚、小檗碱体外释药特性与经皮渗透性存在较好线性相关性。

Abstract

Objective:To study on characteristics of in vitro release and transdermal penetration of Danhuang gel.Method:Modified Franz diffusion cell was used

with berberine and chrysophanol as indexes

in vitro drug release and percutaneous penetration laws of index components were described by kinetic model.Result:Release of chrysophanol could be fitted best by zero-power kinetics model

but berberine by Ritger-Peppas model;Penetration of chrysophanol and berberine in vitro skin were best by fitting for one-power kinetics model;Relevant linear equation of in vitro release and transdermal penetration for chrysophanol could be described as Y=0.468 7X+4.972 2（r=0.966 4）

berberine as Y=0.666 9X+2.487 4（r=0.974 0）

and in vitro release rate was higher than in vitro transdermal rate of two index components in Danhuang gel.Conclusion:In vitro release and transdermal penetration of berberine and chrysophanol had a good linear correlation.

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