正交试验法优选平哮颗粒的提取纯化工艺

张潮; 潘金火; 史锁芳; 严国俊; 史钱平

doi:10.13422/j.cnki.syfjx.2012.18.030

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正交试验法优选平哮颗粒的提取纯化工艺

制剂与工艺 | 更新时间：2024-09-23

- 正交试验法优选平哮颗粒的提取纯化工艺
- Optimization of Extraction and Purification Process for Pingxiao Granule by Orthogonal Test
- 中国实验方剂学杂志 2012年18卷第18期页码：42-45
- 作者机构：
  
  南京中医药大学药学院
- 作者简介：
- 基金信息：
  
  江苏省康缘基金项目（HZ1011KY）
- DOI：10.13422/j.cnki.syfjx.2012.18.030
  中图分类号： R286
- 纸质出版日期：2012
- 稿件说明：
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[1]张潮,潘金火,史锁芳,严国俊,史钱平.正交试验法优选平哮颗粒的提取纯化工艺[J].中国实验方剂学杂志,2012,18(18):42-45.

ZHANG Chao, PAN Jin-huo, SHI Suo-fang, et al. Optimization of Extraction and Purification Process for Pingxiao Granule by Orthogonal Test[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(18): 42-45.
[1]张潮,潘金火,史锁芳,严国俊,史钱平.正交试验法优选平哮颗粒的提取纯化工艺[J].中国实验方剂学杂志,2012,18(18):42-45. DOI： 10.13422/j.cnki.syfjx.2012.18.030.

ZHANG Chao, PAN Jin-huo, SHI Suo-fang, et al. Optimization of Extraction and Purification Process for Pingxiao Granule by Orthogonal Test[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(18): 42-45. DOI： 10.13422/j.cnki.syfjx.2012.18.030.

摘要

目的:优选平哮颗粒的水提醇沉工艺条件。方法:以岀固率、盐酸麻黄碱和芍药苷的总提取率为综合评价指标

采用正交试验法考察浸泡时间、加水量、煎煮次数、煎煮时间4个因素对提取工艺的影响;以盐酸麻黄碱和芍药苷的总转移率为考察指标

正交试验考察药液与药材比例、醇沉时间、醇沉体积分数对醇沉工艺的影响。结果:平哮颗粒的最佳水提工艺为加8倍量水煎煮3次

每次1 h;最佳醇沉工艺为水煎液浓缩至生药质量浓度2 g.mL-1

加乙醇使含醇体积分数达60%

搅匀

静置8 h。结论:该优选工艺可确保有效成分最大限度保留

可用于工业化生产。

Abstract

Objective:To optimize water extraction and alcohol precipitation technology for Pingxiao granule.Method:With solid ratio

total extraction rate of ephedrine hydrochloride and paeoniflorin as comprehensive evaluation indexes

orthogonal test was used to optimize extraction technology with soaking time

the amount of water

decocting times and decocting time as factors;With total transfer rate of ephedrine hydrochloride and paeoniflorin as index

effect of solid-liquid ratio

alcohol precipitation time and the concentration of ethanol on alcohol precipitation technology was optimized by orthogonal test.Result:Optimum water extraction process was as follows:decocted 3 times with 8 times the amount water

1 h each time;Optimum alcohol precipitation process was:the concentration of decoction liquid concentrated 2 g · mL-1

precipitated to the concentration of ethanol 60%

stirred well

stilled 8 h.Conclusion:These optimized technology could ensure effective components saved to the maximum

it could be used for industrial production.

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