Objective:To compare the liver-protective effects between traditional decoction and Chinese medicinal dispensing granule of Sini San.Method:Liver injury models were induced by establishing restraint stress and Propionibacterium acnes-lipopolysaccharide（LPS） in mice.Kunming mice were divided into 7 groups

normal control

stress model

positive control

Sini San decoction（600

1 200 mg · kg-1） and Sini San dispensing granule（600

1 200 mg · kg-1）.Mice were administered for consecutive 6 days and restrained for 18 h.Hepatic function was evaluated by assessing assessing alanine aminotransferase（ALT） and aspartate aminotransferase（AST） level in plasma.Kuming mice were divided into 7 groups

such as normal control

P.acnes-LPS model

positive control

Sini San decoction（600

1 200 mg · kg-1） and Sini San dispensing granule（600

1 200 mg · kg-1）.Mice were injected with 20 mg · kg-1 P.acnes and 5 μg · kg-1 LPS to induce liver injury.Hepatic function was evaluated by ALT and AST level in plasma.Result:Compared with the model groups

the traditional decoction and Chinese dispensing granule of Sini San significantly reduced ALT and AST levels induced by restraint stress or P.acne-LPS.However

there were no significant difference between the two samples.Conclusion:The traditional decoction and Chinese medicinal dispensing granule of Sini San both are effective on improving the liver function in liver-injury mice model.