Objective:To study the mechanism of Shehuang cream on prevention and curing of eczema.Method:Seventy male mice were randomized to control group

model group

Asmanex group

different concentration groups of Shehuang cream

mice delayed hypersensitivity reaction was induced by dinitrofluobenzene;mice pinna and paw swelling were induced by carrageenan to investigate inhibition rate on tumefaction

and the glacial acetic acid induced capillary permeability model was used to evaluate the effect of Shehuang cream and explore it’s mechanism.Sixty SD rats were randomized to control group

model group

Ioratadine group

different concentration groups of Shehuang cream

0.1% phosphoric acid histamine was used to detect the degree of clarification.Sixty-five guinea-pigs were divided into differents groups

guinea pig pruritus were induced by histamine phosphate.Result:Shehuang cream could significantly inhibit the delayed hypersensitivity induced by 2

4-dinitrofluorobanzene（DNFB）

but has no effect on the indexes of thymus and spleen in mice.Shehuang cream could relieve the itch responses in guinea pig and skin permeability in rat induced by histamine（P<0.01）;it also inhibited the auricula inflammation induced by of xylene and enterocoelia capillary permeability by glacial acetic acid in mice（P<0.01）

but had a little action on the paw swelling induced by carrageenan in mice.Conclusion:The results indicte that Shehuang cream’s antipruritic effect may be related to regulation of immune function

antagonistic action on histamine and reducing the inflammatory reaction.