Objective:To investigate protective effects of the compatibility of paeonol and paeoniflorin on experimental myocardial ischemia in rats.Method:Using the method of ligation of left descending coronary artery the rat model of myocardial ischemia was established.Experiment group:sham group

model group

control group

paeonol 100 mg · kg-1+paeoniflorin 25 mg · kg-1

paeonol 50 mg · kg-1 +paeoniflorin 12.5 mg · kg-1

paeonol 25 mg · kg-1 +paeoniflorin 6.25 mg · kg-1.ig 10 mL · kg-1 for 5 d.Sham group and model group was given ig physiological saline.electrocardiogram（ECG）

aspartate

transaminase（AST）

crealine kinase（CK）

lactate dehydrogenase（LDH） and the myocardial infarct size were measured.Result:Compared with the model group

the S-T segment and T waves elevation levels in myocardial ischemia rats in the medium dose and high dose groups of the compatibility of paeonol and paeoniflorin were obviously reduced（P<0.05 or P<0.01）.The myocardial infarct sizes were decreased（P<0.05 or P<0.01）.The content of AST

CK and LDH in rat serum were reduced.Conclusion:The compatibility of paeonol and paeoniflorin can effectively protect myocardial ischemic injury of rats.