Objective:To investigate the poctect function of Diyu Shengbai tabletts on bone marrow depression induced by cyclophosphamide in mice.Method: Twenty-four Balb/C mice

half male and femal

were categorized into three groups.Mice in model group and Diyu Shengbai group were administered cyclophosphamide（Cy）（100 mg · kg-1 once a day for 3 days by intraperitoneal injection） to induce marrow suppression.Diyu Shengbai group was received Diyu Shengbai table treatment（100 mg · kg-1body weight orally once a day for 10 days）.A vehicle treated control group was also arrangeed.The changes of peripheral hemogram

bone marrow nucleated cells（BMCs）

DNA content and bone marrow cell cycle were detected.Result:Cy-treated mice showed a significant decrease in the number of white blood cells

thrombocyte

bone marrow nucleated cell proliferation and the content of DNA in bone（compared with control group

there were significant differences

P<0.05 or P<0.01）.The percentage of G0/G1 phase was increased and the percentage G2/M phase decreased（compared with control group

there were significant differences

P<0.05 or P<0.01）.Diyu Shengbai tablets significantly increased the number of white blood cells

thrombocyte

bone marrow nucleated cell proliferation and markedly increased the percentage of G2/M phase(compared with model group（P<0.05 or P<0.01）.Conclusion:Diyu Shengbai Tablets could improve the hemopoietic function for marrow suppression induced by Cy in mice.