葛根素骨架缓释片的研制及体外释放评价

周珊珊; 谭睿; 谢彬; 马向华; 张娥; 顾健

doi:10.13422/j.cnki.syfjx.2013.03.021

您当前的位置：

首页 >

文章列表页 >

葛根素骨架缓释片的研制及体外释放评价

工艺与制剂 | 更新时间：2024-09-23

- 葛根素骨架缓释片的研制及体外释放评价
- Preparation and in vitro Release Evaluation of Puerarin Sustained-Release Tablet
- 中国实验方剂学杂志 2013年19卷第3期页码：23-26
- 作者机构：
  
  1. 西南交通大学
  2. 西南民族大学
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目（81173594）;四川省应用基础项目（2012JY0025）;成都市科技局项目（11DXYB263JH-027）;中央高校基本科研业务费专项（11NZYTH02）
- DOI：10.13422/j.cnki.syfjx.2013.03.021
  中图分类号： R286.0
- 纸质出版日期：2013
- 稿件说明：
移动端阅览
[1]周珊珊,谭睿,谢彬,马向华,张娥,顾健.葛根素骨架缓释片的研制及体外释放评价[J].中国实验方剂学杂志,2013,19(03):23-26.

ZHOU Shan-shan1, TAN Rui1, XIE Bin1, et al. Preparation and in vitro Release Evaluation of Puerarin Sustained-Release Tablet[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 23-26.
[1]周珊珊,谭睿,谢彬,马向华,张娥,顾健.葛根素骨架缓释片的研制及体外释放评价[J].中国实验方剂学杂志,2013,19(03):23-26. DOI： 10.13422/j.cnki.syfjx.2013.03.021.

ZHOU Shan-shan1, TAN Rui1, XIE Bin1, et al. Preparation and in vitro Release Evaluation of Puerarin Sustained-Release Tablet[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 23-26. DOI： 10.13422/j.cnki.syfjx.2013.03.021.

摘要

目的:研制葛根素骨架缓释片

并评价其体外释药机制。方法:以不同型号的羟丙甲基纤维素（HPMC K100M

HPMC E4M）混合物为骨架材料

采用湿法制粒压片制备葛根素骨架缓释片

以葛根素释放度为指标

采用单因素试验法对缓释片的处方进行优化;通过测定释放度

考察葛根素骨架缓释片的体外释放模型。结果:优选的处方为HPMC K100M和HPMC E4M作为复合骨架材料

质量分数分别为片剂总质量的10%

20%;乳糖为填充剂

质量分数为片剂总质量的30%。制备的葛根素骨架缓释片释放规律符合Ritger-Peppas方程曲线

释药过程为药物扩散和骨架溶蚀协同作用。结论:葛根素骨架缓释片处方合理

制备工艺可行

制备的葛根素骨架缓释片具有良好的12 h体外释药特性。

Abstract

Objective:To prepare puerarin sustained-release tablet and investigate its in vitro release mechanism.Method:With mixture of different types of hydroxypropyl methylcellulose（HPMC K100M

HPMC E4M） as skeleton material

puerarin sustained-release tablet was prepared by wet granulation tabletting method

with release of puerarin as index

formulation of sustained-release tablet was optimized by single factor test;In vitro release model of puerarin skeleton sustained-release tablet was investigated by determining release.Result:Optimized prescription was:HPMC K100M and HPMC E4M as compound matrix

the mass fraction of them were 10%

20%

respectively;Lactose as filler

the mass fraction of it was 30%.Release law of prepared sustained-release tablet complied with Ritger-Peppas equation curve

release process was synergistic reaction of drug diffusion and skeleton dissolution.Conclusion:Prescription of prepared puerarin sustained-release tablet was reasonable

preparation technology was feasible

prepared puerarin sustained-release tablet had good in vitro release characteristics in 12 h.

关键词

Keywords

references

浏览量

391

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

葛根素骨架缓释片的研制及体外释放评价

丹酚酸B-葛根素联用对氧糖剥夺/复氧损伤的SH-SY5Y神经细胞焦亡的影响

中药配方颗粒制备工艺、质量评价、与传统汤剂一致性的研究现状分析

经典名方中煮散和散剂粒度探讨

葛根素通过PI3K/Akt/GSK-3β信号通路调节HepG2细胞胰岛素抵抗