Box-Behnken设计优化黄芩的浸渍-压榨提取工艺

唐梅; 刘剑云; 刘英; 杨金辉; 杨明

doi:10.13422/j.cnki.syfjx.2013.03.031

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Box-Behnken设计优化黄芩的浸渍-压榨提取工艺

工艺与制剂 | 更新时间：2024-09-23

- Box-Behnken设计优化黄芩的浸渍-压榨提取工艺
- Optimization of Impregnating-Squeezing Extraction Technology for Scutellaria baicalensis by Box-Behnken Design
- 中国实验方剂学杂志 2013年19卷第3期页码：58-61
- 作者机构：
  
  1. 成都中医药大学
  2. 江西中医学院中药现代制剂教育部重点实验室
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2013.03.031
  中图分类号： R284
- 纸质出版日期：2013
- 稿件说明：
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[1]唐梅,刘剑云,刘英,杨金辉,杨明.Box-Behnken设计优化黄芩的浸渍-压榨提取工艺[J].中国实验方剂学杂志,2013,19(03):58-61.

TANG Mei1, LIU Jian-yun1, LIU Ying1, et al. Optimization of Impregnating-Squeezing Extraction Technology for Scutellaria baicalensis by Box-Behnken Design[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 58-61.
[1]唐梅,刘剑云,刘英,杨金辉,杨明.Box-Behnken设计优化黄芩的浸渍-压榨提取工艺[J].中国实验方剂学杂志,2013,19(03):58-61. DOI： 10.13422/j.cnki.syfjx.2013.03.031.

TANG Mei1, LIU Jian-yun1, LIU Ying1, et al. Optimization of Impregnating-Squeezing Extraction Technology for Scutellaria baicalensis by Box-Behnken Design[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 58-61. DOI： 10.13422/j.cnki.syfjx.2013.03.031.

摘要

目的:优选黄芩的浸渍-压榨提取工艺。方法:采用浸渍-压榨联合提取法

选取提取时间、提取温度、溶剂倍数为考察因素

以总黄酮、黄芩苷提取率和出膏率的总评归一值（OD）为指标

通过Box-Behnken试验设计优选提取工艺。结果:最佳浸渍-压榨提取工艺为加11倍量水于60℃浸泡4 h

压榨

药渣加2倍量水洗涤后压榨

重复操作1次。总黄酮、黄芩苷提取率分别为17.630%

9.38%

出膏率42.7%

与模型预测值非常接近

说明该模型比较可靠。结论:优选的提取工艺科学、合理、可行

为中药常温提取工艺推广提供参考。

Abstract

Objective:To optimize impregnating-squeezing extraction technology for Scutellaria baicalensis.Method:Impregnating-squeezing joint extraction method was used

with OD of extract rate

yield of total flavonoids and baicalin as index

extraction time

extraction temperature and dosage of solvent were selected as factors

extraction technology was optimized by Box-Behnken design.Result:Optimal impregnating-squeezing extraction technology was as follows:soaked 4 h with 11 times the amount of water at 60 ℃

squeezing extracted

add 2 times water to wash dregs

squeezing extracted

once again.Yield of total flavonoids and baicalin were 17.63%

9.38%

respectively

extract rate was 42.7%

these datas were very close to model predictor

it showed this model was reliable.Conclusion:Optimized extraction technology was scientific

reasonable and feasible

it could provide a reference for promoting ordinary temperature extraction technology.

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