降糖消脂片对KK-A<sup>y</sup>糖尿病肥胖小鼠胰岛素受体及底物表达的影响

郑咏秋; 葛争艳; 金龙; 郭宇洁; 杨斌; 董小霞; 李宏坤; 任烨; 刘建勋

doi:10.13422/j.cnki.syfjx.2013.03.089

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降糖消脂片对KK-A^y糖尿病肥胖小鼠胰岛素受体及底物表达的影响

药理 | 更新时间：2024-09-23

- 降糖消脂片对KK-A^y糖尿病肥胖小鼠胰岛素受体及底物表达的影响
- Effect of Jiangtang Xiaozhi Tablets on Expression of Insulin Receptor β and Insulin Receptor Substrate-1 in KK-A^y Transgenic Mice Model of Diabetes Mellitus
- 中国实验方剂学杂志 2013年19卷第3期页码：175-179
- 作者机构：
  
  中国中医科学院西苑医院实验研究中心
- 作者简介：
- 基金信息：
  
  综合性中药新药研究开发技术大平台（2009ZX09301-005-007）;重大新药创制-中药医院制剂新药研发（2010ZX09102-213）
- DOI：10.13422/j.cnki.syfjx.2013.03.089
  中图分类号： R587.1
- 纸质出版日期：2013
- 稿件说明：
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[1]郑咏秋,葛争艳,金龙,郭宇洁,杨斌,董小霞,李宏坤,任烨,刘建勋.降糖消脂片对KK-A~y糖尿病肥胖小鼠胰岛素受体及底物表达的影响[J].中国实验方剂学杂志,2013,19(03):175-179.

ZHENG Yong-qiu, GE Zheng-yan, JIN Long, et al. Effect of Jiangtang Xiaozhi Tablets on Expression of Insulin Receptor β and Insulin Receptor Substrate-1 in KK-A^y Transgenic Mice Model of Diabetes Mellitus[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 175-179.
[1]郑咏秋,葛争艳,金龙,郭宇洁,杨斌,董小霞,李宏坤,任烨,刘建勋.降糖消脂片对KK-A~y糖尿病肥胖小鼠胰岛素受体及底物表达的影响[J].中国实验方剂学杂志,2013,19(03):175-179. DOI： 10.13422/j.cnki.syfjx.2013.03.089.

ZHENG Yong-qiu, GE Zheng-yan, JIN Long, et al. Effect of Jiangtang Xiaozhi Tablets on Expression of Insulin Receptor β and Insulin Receptor Substrate-1 in KK-A^y Transgenic Mice Model of Diabetes Mellitus[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 175-179. DOI： 10.13422/j.cnki.syfjx.2013.03.089.

摘要

目的:建立糖尿病肥胖小鼠模型

观察降糖消脂片对模型小鼠胰腺胰岛素受体及底物表达的影响。方法:采用KK-Ay转基因小鼠

高脂饲料喂养造成糖尿病肥胖小鼠模型。对照组为同龄C57小鼠

成模的KK-Ay小鼠分为模型组、吡格咧酮组、降糖消脂片高、中、低剂量组（10

2.5 g.kg-1）（11只/组）

连续灌胃给药（ig）8周。每周称体重及摄食量

隔周测血糖。药后8周取胰腺作病理切片

并取胰腺组织检测胰岛素受体及底物表达。结果:降糖消脂片各剂量组明显减轻糖尿病肥胖小鼠体重

降低血糖。病理结果显示:降糖消脂片可减少变性及凋亡的胰岛细胞。糖尿病肥胖模型组小鼠胰腺组织胰岛素受体β（insulin receptorβ

InsRβ）和胰岛素受体底物-1（insulin receptor substrate 1

IRS-1）的表达低于对照组。降糖消脂片可有效诱导InsRβ和IRS-1表达。结论:降糖消脂片对KK-Ay糖尿病肥胖小鼠有明显的治疗作用

并可诱导胰岛素受体及底物表达。

Abstract

Objective:To observe effects of Jiangtang Xiaozhi（JTXZ） tablets on expression of insulin receptor β（InsRβ） and insulin receptor substrate-1（IRS-1） in KK-Ay transgenic mice model of diabetes mellitus（DM）.Method: KK-Ay transgenic mice were used and fed with high-fat diet to induce hyperglycemia as a model of DM obesity.The C57mice with same age of KK-Ay transgenic mice were used as a control group.Thereafter

Fifty-five mice with DM obesity were divided into 5 groups（n=11） including model group without any treatment

pioglitazone hydrochloride tablets treatment group as a positive control group

and JTXZ tablets groups at high

middle and low treatment doses

and were continuously given JTXZ tablets by intragastric administration for 8 weeks.All mice were sacrificed after treatment of 8 weeks.The pathology examination of abdominal salivary gland was performed.The expression of InRβ and IRS-1 were deteced

respectively.Result:In the JTXZ tablets treatment group

compared with that in KK-Ay transgenic mice model with DM obesity

the pancreatic pathological changes were ameliorated significantly.Expression of InRβ and IRS-1 were increased in each treatment group by JTXZ tablets

respectively.Conclusion: JTXZ tablets have obvious effects of increasing levels of InRβ and IRS-1 in KK-Ay transgenic mice model with DM obesity.

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降糖消脂片对KK-Ay糖尿病肥胖小鼠胰岛素受体及底物表达的影响

Effect of Jiangtang Xiaozhi Tablets on Expression of Insulin Receptor β and Insulin Receptor Substrate-1 in KK-Ay Transgenic Mice Model of Diabetes Mellitus

DOI：10.13422/j.cnki.syfjx.2013.03.089

摘要

Abstract

关键词

Keywords

references

降糖消脂片对KK-A^y糖尿病肥胖小鼠胰岛素受体及底物表达的影响

Effect of Jiangtang Xiaozhi Tablets on Expression of Insulin Receptor β and Insulin Receptor Substrate-1 in KK-A^y Transgenic Mice Model of Diabetes Mellitus