风湿宁胶囊中挥发油的提取及包合工艺优选

岳晓华; 段秀俊; 史利霞; 王永辉; 薛慧清; 张海; 周然

doi:10.13422/j.cnki.syfjx.2013.05.005

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风湿宁胶囊中挥发油的提取及包合工艺优选

工艺与制剂 | 更新时间：2024-09-23

- 风湿宁胶囊中挥发油的提取及包合工艺优选
- Optimization of Extraction and Inclusion Technology for Volatile Oil from Anti-rheumatism Capsules
- 中国实验方剂学杂志 2013年19卷第5期页码：22-24
- 作者机构：
  
  1. 山西中医学院
  2. 山西仁源堂药业有限公司
- 作者简介：
- 基金信息：
  
  国家科技重大专项重大新药创制项目（2010ZX09102-210）;山西省科技产业化环境建设项目（2012061014-3）
- DOI：10.13422/j.cnki.syfjx.2013.05.005
  中图分类号： R286;TQ461
- 纸质出版日期：2013
- 稿件说明：
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[1]岳晓华,段秀俊,史利霞,王永辉,薛慧清,张海,周然.风湿宁胶囊中挥发油的提取及包合工艺优选[J].中国实验方剂学杂志,2013,19(05):22-24.

YUE Xiao-hua1, DUAN Xiu-jun1, SHI Li-xia1, et al. Optimization of Extraction and Inclusion Technology for Volatile Oil from Anti-rheumatism Capsules[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 22-24.
[1]岳晓华,段秀俊,史利霞,王永辉,薛慧清,张海,周然.风湿宁胶囊中挥发油的提取及包合工艺优选[J].中国实验方剂学杂志,2013,19(05):22-24. DOI： 10.13422/j.cnki.syfjx.2013.05.005.

YUE Xiao-hua1, DUAN Xiu-jun1, SHI Li-xia1, et al. Optimization of Extraction and Inclusion Technology for Volatile Oil from Anti-rheumatism Capsules[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 22-24. DOI： 10.13422/j.cnki.syfjx.2013.05.005.

摘要

目的:优选风湿宁胶囊中挥发油的提取与包合工艺。方法:采用水蒸气蒸馏法提取挥发油

以提取量为指标

通过单因素试验考察加水量、提取时间对提取工艺的影响;采用饱和水溶液法包合挥发油

以包合率为指标

通过正交试验考察挥发油与β-CD的比例、包合时间及包合温度对包合工艺的影响。结果:最佳提取工艺为加14倍量水提取4 h;最佳包合工艺为挥发油与β-环糊精的比例1∶8

包合温度40℃

包合时间3 h。结论:优选的挥发油提取与包合工艺条件稳定可行。

Abstract

Objective:To optimize extraction and inclusion technology of volatile oil from anti-rheumatism capsules.Method:Volatile oil was extracted by steam distillation method

with yield of volatile oil as index

effect of water amount and extraction time on extraction technology was investigated by single factor test;Volatile oil was inclused by saturated aqueous solution method using inclusion ratio as index

orthogonal test was used to optimize inclusion technology with ratio of volatile oil to β-cyclodextrin

inclusion time and temperature as factors.Result:Optimum extraction conditions were:extracted 4 h with 14 times the amount of water;Optimal inclusion technology was as followings:ratio of volatile oil to β-cyclodextrin 1∶ 8

inclusion tempemture 40 ℃

inclusion time 3 h.Conclusion:These optimized extraction and inclusion technology conditions were reasonable and feasible.

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