熊果苷缓释乳膏的制备工艺优化及体外释放度考察

杨人泽; 丁乐; 严金玲

doi:10.13422/j.cnki.syfjx.2013.05.006

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熊果苷缓释乳膏的制备工艺优化及体外释放度考察

工艺与制剂 | 更新时间：2024-09-23

- 熊果苷缓释乳膏的制备工艺优化及体外释放度考察
- Optimization of Preparation Technology and Investigation of in vitro Release of Arbutin Sustained-release Creams
- 中国实验方剂学杂志 2013年19卷第5期页码：53-56
- 作者机构：
  
  1. 赣南医学院第一附属医院
  2. 赣州市妇幼保健院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2013.05.006
  中图分类号： R283;TQ461
- 纸质出版日期：2013
- 稿件说明：
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[1]杨人泽,丁乐,严金玲.熊果苷缓释乳膏的制备工艺优化及体外释放度考察[J].中国实验方剂学杂志,2013,19(05):53-56.

YANG Ren-ze1, DING Le2, YAN Jin-ling1. Optimization of Preparation Technology and Investigation of in vitro Release of Arbutin Sustained-release Creams[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 53-56.
[1]杨人泽,丁乐,严金玲.熊果苷缓释乳膏的制备工艺优化及体外释放度考察[J].中国实验方剂学杂志,2013,19(05):53-56. DOI： 10.13422/j.cnki.syfjx.2013.05.006.

YANG Ren-ze1, DING Le2, YAN Jin-ling1. Optimization of Preparation Technology and Investigation of in vitro Release of Arbutin Sustained-release Creams[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 53-56. DOI： 10.13422/j.cnki.syfjx.2013.05.006.

摘要

目的:优化熊果苷缓释乳膏的制备工艺

并考察其体外释放度。方法:以平均乳滴数和乳膏均匀度为综合评价指标

选取乳化温度、乳化时间及搅拌速度为考察因素

采用正交设计优化熊果苷缓释乳膏的制备工艺;采用HPLC测定熊果苷含量

考察熊果苷缓释乳膏的体外释放度及稳定性。结果:最佳制备工艺为乳化温度80℃

乳化时间20 min

搅拌速度为以1 200 r.min?1搅拌20 min

停止加热

以500 r.min-1搅拌直至冷却。制得的熊果苷缓释乳膏具有明显的缓释作用和良好的稳定性。结论:优选的制备工艺稳定可行

所得样品具有良好的缓释效果

适用于熊果苷缓释乳膏的工业化生产。

Abstract

Objective:To optimize preparation technology of arbutin sustained-release creams and investigate its in vitro release.Method:With average number of milk drops and creams uniformity as comprehensive evaluation index

orthogonal test was used to optimize preparation technology of arbutin sustained-release creams with emulsification temperature

emulsification time and stirring speed as factors;The content of arbutin was determined by HPLC

in vitro release and stability of arbutin sustained-release creams were investigated.Result:Optimum preparation technology was as following:emulsifying temperature 80 ℃

emulsifying time 20 min and stirring with 1 200 r·min-1 for 20 min

then stopped heating

and stirred with 500 r·min-1 until cooled.Prepared arbutin sustained-release creams showed obvious sustained-release effect and good stability.Conclusion:Optimized preparation technology was stable and feasible

prepared samples had good sustained-release effect

it was suitale for industrial production of arbutin sustained-release creams.

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