Objective:To investigate the prevention and treatment effect of pre-treatment of Shenjing Fuzheng prescription（SFP） for bone marrow suppression induced by radiotherapy in patients with esophageal cancer.Method: Seventy patients suffered from esophageal cancer with routine radiotherapy were randomized into observation group and control group（n=35 each）.The controls were orally given leucogen 20 mg tid daily parallel to radiotherapy.The patients in the observation group were given SFP daily parallel to radiotherapy.The interventions in the two-group were lasted until the end of radiotherapy.Bone marrow suppression and quality of life were evaluated.Result: WBC count levels in the observation group on 14

21

35

42 d were higher than those in control group（P<0.01）.The cases of III degree bone marrow suppression in the observation group appeared less than that in the control group（P<0.05）

and with delayed duration of emerging（P<0.01）.In the observation group

hemoglobin

platelet count and granulocyte count were higher than those in the controls（P<0.01）;clinical symptoms scores were lower than that in the controls（P<0.01）;and Karnofsky score higher than that in the controls（P<0.05）.In the observation group

the consume of recombinant human granulocyte colony stimulating factor was less than that in the controls（P<0.01）.Conclusion: SFP can be used for prevention and treatment of bone marrow suppression caused by radiotherapy in esophageal cancer

and reduce the clinical side effects

improve patients′ quality of life.