Objective:To study the effects of Lycium barbarum polysaccharides（LBP） on lipid metabolism and oxygen free radicals in hyperlipidemic rats.Method: Sixty Wistar rats were randomly divided into six groups: normal control group

high-lipid model group

LBP high

medium and low-dose group and positive control group.The rat model of hyperlipidemic was established by high-fat diet feeding.After 4 weeks

the rats were given with LBP（80

40

20 mg·kg-1） and simvastatin 2 mg·kg-1.At the end of 4 weeks

the abdominal aortic blood was collected and determined total cholesterol（TC）

triglyceride（TG）

low density lipoprotein cholesterol（LDL-C）

high density lipoprotein cholesterol（HDL-C）

superoxide dismutase（SOD）

malondialdehyde（MDA） and glutathione peroxidase（GSH-Px）.Result: Compared with hyperlipidemia model group

serum TC

TG

LDL-C level in each treatment group decreased significantly（P<0.05 or P<0.01）

HDL-C significantly increased（P<0.05）;SOD and GSH-Px activity significantly increased（P<0.05 or P<0.01）

MDA levels decreased significantly（P<0.05 or P<0.01）.Conclusion: LBP could adjust the level of lipid metabolism of rat model of hyperlipidemia

inhibit the damage from oxygen free radicals

prevent lipid peroxidation

and delay atherosclerotic formed.