Objective:To explore the effect of Dihuang Yinzi on the expression of Bax

Bcl-2 and Caspase-3 proteins and protective cerebral mechanism after cerebral ischemia reperfusion.Method: Sixty SD rats were selected and randomized into six groups: sham group

model group and high

medium

low dose groups of Dihuang Yinzi（32

16

8 g·kg-1） and nimodipine positive drug group（1 mg·kg-1）

each involved ten rats.The cerebral ischemia/reperfusion model was established.The expression of Bax

Bcl-2 and Caspase-3 proteins were detected 120 min after cerebral ischemia/reperfusion treated by Dihuang Yinzi.Result: The expression of Bax and Caspase-3 proteins in the models were significantly higher than those in the sham group（P<0.05）.The expression of Bcl-2 proteins in the model group were significantly lower than those in the sham group（P<0.05）.While the expression of Bax and Caspase-3 proteins in the treatment group were significantly lower than those in the model group（P<0.05）

the expression of Bcl-2 proteins in the treatment group were significantly higher than those in the model group（P<0.05）.Conclusion: Dihuang Yinzi can upregulate the expression of Bcl-2 protein and downregulate the expression of Bax and Caspase-3 proteins.Dihuang Yinzi may protect the cerebral injury induced by ischemia/reperfusion through inhibiting neuron apoptosis.