淫羊藿黄酮类组分表观溶解度和油水分配系数的测定

谈唯; 丁冬梅; 张振海; 孙娥; 徐凤娟; 贾晓斌

doi:10.13422/j.cnki.syfjx.2014100005

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淫羊藿黄酮类组分表观溶解度和油水分配系数的测定

工艺与制剂 | 更新时间：2024-01-04

- 淫羊藿黄酮类组分表观溶解度和油水分配系数的测定
- Determination of Apparent Solubility and Oil/water Partition Coefficient of Flavonoid Components from Epimedii Folium
- 中国实验方剂学杂志 2014年20卷第10期页码：5-7
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目（81274088）
- DOI：10.13422/j.cnki.syfjx.2014100005
  中图分类号： R284.1
- 纸质出版日期：2014
- 稿件说明：
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谈唯, 丁冬梅, 张振海, 等. 淫羊藿黄酮类组分表观溶解度和油水分配系数的测定[J]. 中国实验方剂学杂志, 2014,20(10):5-7.

TAN Wei, DING Dong-mei, ZHANG Zhen-hai, et al. Determination of Apparent Solubility and Oil/water Partition Coefficient of Flavonoid Components from Epimedii Folium[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(10): 5-7.
谈唯, 丁冬梅, 张振海, 等. 淫羊藿黄酮类组分表观溶解度和油水分配系数的测定[J]. 中国实验方剂学杂志, 2014,20(10):5-7. DOI： 10.13422/j.cnki.syfjx.2014100005.

TAN Wei, DING Dong-mei, ZHANG Zhen-hai, et al. Determination of Apparent Solubility and Oil/water Partition Coefficient of Flavonoid Components from Epimedii Folium[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(10): 5-7. DOI： 10.13422/j.cnki.syfjx.2014100005.

摘要

目的：测定淫羊藿黄酮类组分的表观溶解度和油水分配系数，为该组分整体水溶性和脂溶性的表征提供参考。方法：以淫羊藿黄酮类组分为模型药物，采用HPLC测定朝藿定A，B，C及淫羊藿苷在不同缓冲液中的平衡溶解度和表观油水分配系数（Papp），流动相乙腈-水（25∶75），检测波长270 nm。结果：朝藿定A，B，C和淫羊藿苷在不同pH缓冲液中的整体平衡溶解度顺序为朝藿定B>朝藿定A>朝藿定C>淫羊藿苷，Papp总体变化趋势均为先变大后变小再变大，油水分配系数-1.437~3.147。结论：淫羊藿黄酮类组分的水溶性及脂溶性较好，在不同pH缓冲液中变化趋势相近，朝藿定B属于微解，朝藿定A，C和淫羊藿苷属于极微溶解。

Abstract

Objective: To determine apparent solubility and apparent oil/water partition coefficient of flavonoid components from Epimedii Folium

so as to lay foundation for overall solubility characterization of these components. Method: Taking flavonoid components from Epimedii Folium as model drug

HPLC was adopted to determine equilibrium solubilities and apparent oil/water partition coefficients(Papp) of epimedin A

C and icariin in different pH buffers by taking mobile phase of acetonitrile-water(25:75) and detection wavelength at 270 nm. Result: Overall equilibrium solubilities of flavonoid components from Epimedii Folium in different pH buffers were in order of epimedin B>epimedin A>epimedin C>icariin

oil/water partition coefficients were -1.437-3.147

overall trends of Papp were changed from small to large and then to small

to large at last. Conclusion: Water-soluble and fat-soluble of flavonoid components from Epimedii Folium were well with a similar overall trend

epimedin B belonged to slightly soluble

epimedin A

C and icariin belonged to very slightly soluble.

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