Objective: To investigate anti-inflammatory of Juanbi particle and its relative mechanisms

to clarify the scientific basis of superior efficiency of Chinese medicine in the clinical treatment on Bi Syndrome (wind-cold-dampness Bi) according to Wu School based on strengthening yang theory. Method: The model of carrageenan-induced edema of rat hind and formation of cotton ball granulom in rats were adopted to investigate anti-inflammatory of Juanbi particle

rats were divided into five groups

including the model group

the positive control group(dexamethasone

Dex

2.5 mg·kg-1)

Juanbi particle group(5.85

11.70

23.40 g·kg-1).Type Ⅱ bovine collagen(CⅡ)-induced arthritis (CIA) in DBA/1 mice were established for investigating the antiarthritic potential of Juanbi particle. The histological damage was assessed by histological examination (HE)

the inflammatory cytokine production levels of interleukin(IL)-6

IL-17A and tumor necrosis factor-α(TNF-α) in CⅡ-induced splenic lymphocytes was detected by cytometric bead array (CBA). Result: Compared with the model group

high dosage group of Juanbi particle and positive control group were significantly inhibited swelling of paw and the formation of cotton ball granuloma(P<0.05); meanwhile the clinical score and inflammatory cells infiltration in CIA mice were significantly reduced in the Juanbi particle administration group. Compared with the normal group

there are significantly increased the inflammatory cytokine level of IL-17A

IL-6 and TNF-α induced by CⅡ (P<0.01). Compared with the model group

the inflammatory cytokine level of IL-17A was reduced by the Juanbi particle (P<0.05)

while the IL-6 and TNF-α have no significant changed. Conclusion: Juanbi particle has an anti-inflammatory effect

the mechanism of which may be related to suppress inflammatory cytokine production levels of IL-17A.