Objective: To study Qili Qiangxin capsule(QL)' s function in improves the chronic heart failure rats' cardiac function and its' influence in the aquaporin-2 Water channel expression

then discuss benefit of how Qili Qiangxin therapies for disorders that chronic heart failure rats' aberrant water movement. Method: The proximal left anterior descending branch (LAD) of coronary artery was ligated using a terylene suture in acute myocardial infarction(AMI) rats

after building AMI model successfully

survivors were randomly divided into four groups

model group (equal volume of water)

QL group (1 g·kg-1·d-1)

valsartan group (10 mg-1·kg-1·d-1)

sham-operated group (equal volume of water) .Drug intervention four weeks

then detection of related indicators. Echocardiography and the expressions of aquaporin-2 were detected by the method of immunohistochemistry and western blotting were assessed 4 weeks after the drug therapy. Result: Compared with the sham-operated group

the left ventricular end-diastolic dimension(LVEDD) and left ventricular end-systolic dimension(LVESD) of model group is significantly increased

ejection fractions(EF) and factional shortening(FS) was significantly lower (P<0.05); compared with model group

QL group LVEDD and LVESD is significantly reduced

EF and FS were significantly higher (P<0.05). There was no significant difference between QL group and valsartan group; compared with the sham-operated group

the aquaporin-2 water channel expression levels were significantly higher in model group(P<0.05); compared with the model group

the AQP-2 expression were reduced to varying degrees in QL and valsartan group (P<0.05); while there was no significant difference between QL group and valsartan group. Conclusion: QL can be effectively reduced AQP-2 expression levels

improve chronic heart failure caused by the water metabolism

elimination of edema symptoms

thereby improving the quality of life in patients with chronic heart failure.