Objective: Biyuan Tongqiao granule for chronic sinusitis in children clinical effect mechanism of action. Method: One hundred and twenty patients were randomly divided into control group (60 cases) and observation group (60 cases).Patients the control group were treated with amoxicillin and clavulanate potassium suspension

4-7 years old

1 sack/time

2 times/day

7-12 years old

1.5 sack/time

2 times/day.The treatment course of the group was 4 weeks. Ambroxol granule

1.2-1.6 mg·kg-1

taken orally by 2-3 times.The treatment course of the group was 6 weeks. Standard myrtol standardized enteric coated soft capsules(children pack)

120 mg/time

3 times/day.The treatment course of the group was 6 weeks.The observation group was added Biyuan Tongqiao granule based on the control group

5-10 g/time

3 times/day.The treatment course of the group was 6 weeks. Determining nasal mucosa transport time(MTT).Detection of serum interleukin-2(IL-2) and interleukin-6(IL-6)

with endoscopy

the results were evaluated by Lund-Kennedy score method

recordding main symptoms and sign grade before and after treatment. Result: The total effective rate of the observation group was 95% superior to 81.7% of the control group(P<0.05)

after treatment

the level of IL-2 and IL-6 in the observation group were lower than those in the control group(P<0.01)

after 3 months of treatment

MTT and Lund-Kennedy score in the observation group were lower than those in the control group(P<0.01)

For the observation group

the symptom such as nasal obstruction

streamed pus nasal discharge

headache

back to the sputum suction and hyperemia swelling of nasal mucosa symptoms and sign grades were all lower than those in the control group(P<0.01). Conclusion: Biyuan Tongqiao granule was used to chronic sinusitis in children patients

It can inhibit the proinflammatory factor and promote the nasal mucosa cilia function

improve the clinical symptoms of patients and sign when when

Have certain curative effect in clinic.