Objective: The purpose is to observe recent curative effect of Yuyang Xiaokui decoction in the treatment of ulcerative colitis (UC) active stage and its influence on the leukocyte betweenness-17

21 (IL-17

IL-21). Method: Ninety cases of patients with UC were randomly divided into control group (45 cases) and observation group (45 cases) according to numeric method. The patients in control group took the mesalazin enteric-coated tablets

to swallow not chew

1 g/time

4 times/day. For patients in observation group

they took Yuyang Xiaokui I decoction on the basis of the control group

1 dose/day

conventional water decoction

orally

2 times;Yuyang Xiaokui Ⅱ decoction

1 dose/day

severe times boiling concentration to 120 mL

enema before sleeping

continue 5 days before 2 days suspend. The treatment course was 8 weeks. The Sutherland disease activity index (Sutherland DAI) was recorded before and after treatment and the response rate was calculated. The colonoscopy expression and colon tissue pathological changes were observed. The main symptoms

signs score were recorded before and after the treatment and the level of serum IL-17

IL-21 was detected. Result: After treatment

the Sutherland DAI

colonoscopy performance score and intestinal tissue pathological change score of two groups were decreased (P<0.01)

while the related scores of observation group were all lower than the control group (P<0.01). The diarrhea

purulent blood

abdominal pain

abdominal distension

anus hot

anal congestion edema and erosion rate were decreased (P<0.01)

while the main symptoms and related scores of observation group were all lower than the control group (P<0.01). There are 31 cases remission in observation group and 20 cases remission in control group with remission rate 68.9% and 44.4%

respectively. The observation group is better than that of control group (P<0.01). The levels of serum IL-17

IL-21 of two groups were decreased after treatment (P<0.01)

while the level of serum IL-17

IL-21 of observation group is lower than the control group (P<0.01). Conclusion: The oral taking and enema of Yuyang Xiaokui decoction can reduce degree of disease activity of patients with UC in light and moderate degree of active stage

alleviate clinical symptoms and sign of patients with UC and promote it into remission. Its mechanism may be related to reduce inflammatory reaction that mediated by Th17 cells.