注射用血塞通对急性脑梗死血栓形成的影响

程明霞; 李海燕; 齐尚书

doi:10.13422/j.cnki.syfjx.2014100196

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注射用血塞通对急性脑梗死血栓形成的影响

临床 | 更新时间：2024-01-04

- 注射用血塞通对急性脑梗死血栓形成的影响
- Influence of Xuesaitong Injection to Forming of Acute Cerebral Infarction
- 中国实验方剂学杂志 2014年20卷第10期页码：196-200
- 作者机构：
- 作者简介：
- 基金信息：
  
  河南省卫生厅创新人才工程基金（豫卫科[2010]52号）
- DOI：10.13422/j.cnki.syfjx.2014100196
  中图分类号： R743.33
- 纸质出版日期：2014
- 稿件说明：
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程明霞, 李海燕, 齐尚书. 注射用血塞通对急性脑梗死血栓形成的影响[J]. 中国实验方剂学杂志, 2014,20(10):196-200.

CHENG Ming-xia, LI Hai-yan, QI Shang-shu. Influence of Xuesaitong Injection to Forming of Acute Cerebral Infarction[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(10): 196-200.
程明霞, 李海燕, 齐尚书. 注射用血塞通对急性脑梗死血栓形成的影响[J]. 中国实验方剂学杂志, 2014,20(10):196-200. DOI： 10.13422/j.cnki.syfjx.2014100196.

CHENG Ming-xia, LI Hai-yan, QI Shang-shu. Influence of Xuesaitong Injection to Forming of Acute Cerebral Infarction[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(10): 196-200. DOI： 10.13422/j.cnki.syfjx.2014100196.

摘要

目的：探讨注射用血塞通对急性脑梗死的疗效和对血栓形成的影响及作用机制。方法：将63例急性期脑梗死患者随机按入院顺序分为对照组30例和观察组33例。两组均参照“中国急性缺血性脑卒中诊治指南2010”给予相应的内科治疗处理。抗凝采用拜阿司匹林肠溶片，100 mg/次，1次/d，晚饭后服用。观察组在对照组治疗的基础上加用注射用血塞通，0.4 g/次，静脉滴注，1次/d。两组疗程均为14 d。采用美国国立卫生研究院卒中量表（NIHSS）量表评估神经功能缺损严重程度，分别于第7，14天评价；检测治疗前后抗凝酶Ⅲ（ATⅢ）、纤维蛋白原（FIB）、定D-二聚体（D-D）、血小板计数，血小板体积分布宽度（PDW）、平均血小板体积（MPV）、大型血小板比率（P-LCR）、血小板聚集率（MPAR）、血栓素B2（TXB2）及6-酮-腺素F_la（6-Keto-PGF_la）变化。结果：经Ridit分析，观察组临床疗效优于对照组（P<0.05）；治疗后7 d，两组NIHSS评分均比治疗前下降（P<0.01）；治疗后14 d，两组NIHSS评分继续下降（P<0.01），观察组NIHSS评分低于对照组（P<0.01）；治疗后观察组FIB，D-D及MPAR均低于对照组（P<0.01），ATⅢ高于对照组（P<0.01）；观察组治疗后PDW，MPV较治疗前减小，P-LCR较治疗前减少，与治疗后对照组比较，差异也有统计学意义（P<0.05或P<0.01）；治疗后观察组TXB2水平低于对照组，6-Keto-PGF_la水平高于对照组（P<0.01）。结论：注射用血塞通可通过多途径的抗血小板聚集、抑制血栓形成作用，改善急性脑梗死患者梗死区及其周围半暗带的血液供应，促进神经功能的恢复。

Abstract

Objective: Discussing curative effect of Xuesaitong injection on acute cerebral

the influence to thrombosis and mechanism of action. Method: Sixty three cases with acute cerebral infarction randomly divided into control group (30 cases) and observation group (33 cases).Both groups' patients received medical treatment refer to 'Chinese Cerebral Ischemic Stroke Treatment Guidelines in 2010'.Anticoagulant use worship aspirin enteric-coated tablets

100 mg/time

1 time/day

taken orally after dinner.Based on treatment of the control group

patients in the observation group added Xuesaitong injection

0.4 g/time

intravenous drip

1 time/day.Course of treatment in two groups was 14 days. Severity degree of neurologic impairment by national institutes of health stroke scale (NIHSS). In 7

the 14 day evaluation

detecting the change of antithrombase (ATⅢ)

fibrinogen(FIB)

given D-dimer(D-D)

blood platelet count

platelet volume distribution width (PDW)

mean platelet volume (MPV)

large platelet ratio (P-LCR)

platelet aggregation rate (MPAR)

thromboxance B2(TXB2) and 6-keto-prostaglandin F_la (6-Keto-PGF_la) before and after treatment. Result: Analyzed by ridit

clinical curative effect in the observation group was superior to the control group(P<0.05).At the seventh day after treatment

NIHSS scores in the two groups decreased(P<0.01).At the fourteenth day after treatment

NIHSS scores in the two groups sequentially decreased(P<0.01)

and NIHSS score in the observation group was lower than the control group(P<0.01).After treatment

FIB

D-D and MPAR in the observation group were all lower than the control group(P<0.01)

ATⅢ was higher than the control group(P<0.01).Compared with the time before treatment

PDW

MPV and P-LCR in the observation group reduced

and compared with the control group after treatment

which also meant a statistical significance from the differences between two groups(P<0.05 or P<0.01).The level of TXB2 in the observation group was lower than the control group

and 6-Keto-PGF_la was higher than the control group(P<0.01). Conclusion: Xuesaitong injection can antiplatelet aggregative

restrain forming thrombosis by several routes

ameliorated acute cerebral infarction region and blood supplying of penumbra around

and improve the recovery of nerve function.

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