Objective:To optimize extraction and purification processes of Shengmai dispersible tablets. Method:Taking composite score of contents of ginsenoside Rg1

Re and yield of extract as index

orthogonal design was adopted to investigate effects of ethanol concentration

solid-liquid ratio

extracting time on extraction process;Chitosan flocculation sedimentation method was employed

orthogonal test was adopted to optimize purification technology with concentration degree of extracting solution

dosage of chitosan

standing time as factors. Result:The best extraction process was as follows:extracted thrice with eight times the amount of 85% ethanol for 2 h each time;contents of ginsenoside Rg1 and Re were 0.251% and 0.074%.Optimum purification process was as following:the concentration of extracting solution 1 g·mL-1

dosage of chitosan 10%

standing time for 12 h; contents of ginsenoside Rg1 and Re were 0.394% and 0.116%. Conclusion:This optimized process was stable and feasible for providing a reference to dosage-form reformation of Shengmai dispersible tablets.