Objective:To develop an GC method of determining the characteristic chromatographic profile of Chrysanthemi Indici Flos for controlling the drug quality quickly and accurately. Method:The separation was performed on HP-5 (0.25 μm×0.32 mm×30 m); the column oven was begun at 60 ℃ and held 2 min

then programmed from 60 ℃ to 105 ℃ at 4 ℃·min-1

then programmed from 105 ℃ to 115 ℃ at 2 ℃·min-1

then programmed from 115 ℃ to 250 ℃ at 15 ℃·min-1 held 2 min; by using helium as the carries gas

the flow rate is 1 mL·min-1

the split ratio is 20:1; hydrogen flame ionization detector; injector temperature was 250 ℃

detector temperature was 250 ℃. Result:To analyse 12 batches of volatile oil

the fingerprints of Chrysanthemi Indici Flos from different areas were established. The fingerprint similarity of S1

S2

S8 is in 0.781-0.843.The fingerprint similarity of S3

S4

S7

S10 is in 0.853-0.932.The fingerprint similarity of the rest of the samples is above 0.95. Conclusion:This method is reproducible

simple and easy

and can be used to provide a base for the quality control of Chrysanthemi Indici Flos.