烧伤愈合软膏及其水凝胶中3种小檗碱型生物碱的药动学分析

徐彬; 陈永刚; 邹吉利; 吴金虎

doi:10.13422/j.cnki.syfjx.2014110099

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烧伤愈合软膏及其水凝胶中3种小檗碱型生物碱的药动学分析

药物代谢 | 更新时间：2024-01-04

- 烧伤愈合软膏及其水凝胶中3种小檗碱型生物碱的药动学分析
- Pharmacokinetics of Three Alkaloids in Burn Healing Creams and Its Hydrogels
- 中国实验方剂学杂志 2014年20卷第11期页码：99-102
- 作者机构：
- 作者简介：
- 基金信息：
  
  湖北省科技计划自然科学基金（2011CDB298）
- DOI：10.13422/j.cnki.syfjx.2014110099
  中图分类号： R285
- 纸质出版日期：2014
- 稿件说明：
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徐彬, 陈永刚, 邹吉利, 等. 烧伤愈合软膏及其水凝胶中3种小檗碱型生物碱的药动学分析[J]. 中国实验方剂学杂志, 2014,20(11):99-102.

XU Bin, CHEN Yong-gang, ZOU Ji-li, et al. Pharmacokinetics of Three Alkaloids in Burn Healing Creams and Its Hydrogels[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(11): 99-102.
徐彬, 陈永刚, 邹吉利, 等. 烧伤愈合软膏及其水凝胶中3种小檗碱型生物碱的药动学分析[J]. 中国实验方剂学杂志, 2014,20(11):99-102. DOI： 10.13422/j.cnki.syfjx.2014110099.

XU Bin, CHEN Yong-gang, ZOU Ji-li, et al. Pharmacokinetics of Three Alkaloids in Burn Healing Creams and Its Hydrogels[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(11): 99-102. DOI： 10.13422/j.cnki.syfjx.2014110099.

摘要

目的：建立大鼠血浆中盐酸黄连碱、盐酸巴马汀和盐酸小檗碱的HPLC测定，比较烧伤愈合软膏及其水凝胶中3种生物碱的生物利用度。方法：制备大鼠深二度烫伤模型，创面分别按0.02 g·g-1剂量给予烧伤愈合软膏及其水凝胶，通过HPLC测定不同采血点血浆中3种生物碱的含量，采用PKsolver 2.0软件拟合求算药动学参数。结果：3种生物碱的药-时曲线呈非房室模型，水凝胶组中生物碱在大鼠体内的生物利用度优于烧伤愈合软膏组，水凝胶组中3种生物碱的Cmax提高了1.2~2.6倍，AUC0-24 h提高了1.2~1.7倍。结论：建立的HPLC简单、可靠，可用于小檗碱型生物碱血药浓度分析及其药代动力学分析；烧伤愈合软膏及其水凝胶经皮吸收迅速，释放缓慢。

Abstract

Objective:To establish a sensitive and specific HPLC method for determination of plasma concentrations of three alkaloids in rats plasma and compare their bioavailabilities in burn healing ointments and hydrogels. Method:Deep Ⅱ scald model of rats was established

wound were given burn healing ointments and hydrogels with 0.02 g·g-1

respectively.Then plasma concentrations of three alkaloids at different time points were determined by HPLC and major pharmacokinetic parameters were estimated by PKsolver 2.0 software. Result:Concentration-time curves of three alkaloids conformed to a atriovertricular model

in vivo bioavailability of three alkaloids in hydrogels group were superior to ointments group

compared to the latter

the former existed 120%-260% increases in Cmax and 120%-170% increases in AUC0-24 h. Conclusion:This established HPLC method was simple and sensitive to determine concentrations of three alkaloids in rats plasma and could be used for pharmacokinetic analysis;it could find that two dosage forms were quickly absorded and slowly released.

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