复方丹参滴丸与西药联合治疗外伤性癫痫

李桂云; 邓咣邑; 牛毓茜

doi:10.13422/j.cnki.syfjx.2014110185

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复方丹参滴丸与西药联合治疗外伤性癫痫

临床 | 更新时间：2024-01-04

- 复方丹参滴丸与西药联合治疗外伤性癫痫
- Analysis of Clinical Efficacy and Safety of Compound Danshen Dripping Pill Combined with Western Medicine in Treatment of Post Traumatic Epilepsy
- 中国实验方剂学杂志 2014年20卷第11期页码：185-188
- 作者机构：
- 作者简介：
- 基金信息：
  
  贵州省自然科学基金项目（201203698）
- DOI：10.13422/j.cnki.syfjx.2014110185
  中图分类号： R742.1
- 纸质出版日期：2014
- 稿件说明：
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李桂云, 邓咣邑, 牛毓茜. 复方丹参滴丸与西药联合治疗外伤性癫痫[J]. 中国实验方剂学杂志, 2014,20(11):185-188.

LI Gui-yun, DENG Guang-yi, NIU Yu-qian. Analysis of Clinical Efficacy and Safety of Compound Danshen Dripping Pill Combined with Western Medicine in Treatment of Post Traumatic Epilepsy[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(11): 185-188.
李桂云, 邓咣邑, 牛毓茜. 复方丹参滴丸与西药联合治疗外伤性癫痫[J]. 中国实验方剂学杂志, 2014,20(11):185-188. DOI： 10.13422/j.cnki.syfjx.2014110185.

LI Gui-yun, DENG Guang-yi, NIU Yu-qian. Analysis of Clinical Efficacy and Safety of Compound Danshen Dripping Pill Combined with Western Medicine in Treatment of Post Traumatic Epilepsy[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(11): 185-188. DOI： 10.13422/j.cnki.syfjx.2014110185.

摘要

目的：探讨复方丹参滴丸与西药联合治疗外伤性癫痫（post traumatic epilepsy，PTE）的临床疗效与安全性。方法：将2012年2月-2013年2月在贵阳市第二人民医院接受诊断与治疗的急性中、重度脑外伤所致癫痫患者按照随机数字表法随机分为研究组和对照组，其中研究组采用复方丹参滴丸与西药联合治疗，而对照组则仅采用常规抗癫痫西药对症治疗，3个月后观察疗效并比较两组患者治疗前后及癫痫发作时的血清肿瘤坏死因子（TNF-α）、白细胞介素-6（IL-6）、C反应蛋白（CRP）含量水平。结果：两组患者经过3个月治疗后，研究组患者中满意28例，显著改善8例，良好4例，效差4例，总有效率达93.62%；对照组患者中满意20例，显著改善7例，良好5例，效差5例，总有效率达78.72%；经统计学分析发现研究组的总有效率（93.62%）明显高于对照组（78.72%）（P<0.05）。研究组和对照组患者在治疗后血清TNF-α，IL-6及CRP水平均较本组治疗前、发作时明显下降（P<0.05）；另外，研究组治疗后的血清TNF-α，IL-6及CRP水平亦较对照组治疗后水平明显下降（P<0.05）。两组患者的不良反应发生率比较无明显差异。结论：复方丹参滴丸与西药联合治疗外伤性癫痫的具有改善症状、疗效确切、不良反应发生率低等特点，优于单纯西医治疗，可以有效促进神经细胞功能恢复，作用机制可能与其降低血清TNF-α，IL-6与CRP值有关。

Abstract

Objective:To investigate the clinical efficacy and safety of compound Danshen dripping pill combined with western medicine in treatment of post traumatic epilepsy. Method:From February 2012 to February 2013 year post traumatic epilepsy patients in Guiyang Second People's Hospital were randomly divided into study group and control group. The study group were treated with combined with compound Danshen dripping pill and western medicine

while the control group was only used routine antiepileptic western medicine. 3 months after treatment

the therapeutic effects were observed and serum tumor necrosis factor-α(TNF-α) compared two groups of patients before and after treatment of seizures TNF-α

interleukin-6 (IL-6)

C reactive protein (CRP) levels. Result:After 3 months of treatment

28 cases were satisfied with the study

significantly improved in 8 cases

good in 4 cases

4 cases were effective

the total effective rate was 93.62%; the control group 20 cases with patients

significantly improved in 7 cases

good in 5 cases

poor effects in 5 cases

the total effective rate of 78.72%; the statistics found that efficiency study group analysis (93.62%) was significantly higher than the control group (78.72%)

and the difference was statistically significant (P<0.05). The study group and the control group of patients after treatment

serum TNF-α

IL-6 and CRP levels were compared to attack the group before treatment

decreased obviously(P<0.05); in addition

the study group after treatment

the serum TNF-α

IL-6 and CRP levels than the control group after treatment were decreased(P<0.05). Adverse reactions of the two groups were compared the incidence of no significant difference. Conclusion:The curative effect of compound Danshen dripping pill combined with western medicine in treatment of post traumatic epilepsy is good

and adverse reaction rate is low

better than western medicine treatment. It can effectively promote the functional recovery of nerve cells

and the mechanism may be related to the decrease of serum TNF-α

IL-6 and CRP.

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