Objective:Discuss the clinical curative effect of iontophoresis Xianfang Huoming decoction jiawei knee osteoarthritis(KOA) after arthroscopic debridement and the influence to the level of knee joint fluid tumor necrosis factor-α(TNF-α) and interlcukin-1β (IL-1β). Method:One hundred cases with KOA were randomly divided into control group (50 cases) and observation group (50 cases)by random number table.Both of the tow groups' patients received arthroscopic debridement treatment

after the operation

patients in the control group took sodium hyaluronate 20 mL

intraarticular injection

1 time/week

continued 5 weeks.After 1 week of the operation

patients in the observation group used iontophoresis of Xianfang Huoming decoction jiawei

2 times/day

continued 4 weeks.Evaluating degree of patients' pain by visual analogue scales(VAS)method. Evaluating the function of patients' knee joint by Lysholm articular's function scores

and evaluating the function of knee joint flexion and extension.Detecting the level of tumor necrosis factor-α(TNF-α) and interlcutin-1β(IL-1β) in synovial fluid.And the time of evaluation were the before treatment and 6 weeks after treatment. Result:Analyzed by Ridit

after treatment

the clinical curative effect of the observation group was superior to the control group(P<0.05)

compared with the time before treatment

after 6 weeks of the operation

the scores of VAS and the function of knee joint flexion and extension in the groups decreased obviously(P<0.01)

but Lysholm's raised obviously(P<0.01). The scores of VAS and the function of knee joint flexion and extension in the observation group were lower than those in the control group(P<0.01)

but Lysholm's were higher (P<0.01). After 6 weeks of the operation

for the two groups

the level of TNF-α and IL-1 in synovial fluid decreased

and the level of TNF-α and IL-1 in the observation group were lower than those in the control group(P<0.01). Conclusion:The Xianfang Huoming decoction jiawei iontophoresis in the treatment of KOA after arthroscopic surgery patients

the relief of pain and other symptoms

to synovial fluid reduce in of IL-1β and TNF-α levels

Recovery of knee joint function.