Objective:Observe clinical curative effect of maintenance treatment of Fuzheng Xiaoji decoction to breast cancer after surgical treatment. Method:One hundred and four cases were randomly divided into control group and observation group refer to different treatments.Patients in control group(53 cases) received normative radiotherapy

chemotherapy

endocrinotherapy

targeted therapy and positive symptomatic treatment.Based on the control group

the observation group of (51 cases) the control group the use of Fuzheng Xiaoji decoction based on syndrome differentiation

1 dose/day

conventional water frying

taking 2 times.After 3 to 6 months

taking orally by paste.Total course of treatment was 3 years.Disease free survival(DFS) was recorded

and before treatment

in sixth mouth and twelfth mouth after treatment

patients' quality of life was evaluated by quality of life questionnaire of breast cancer patients(QLQ-BR53).Before treatment

in sixth mouth after treatment

T lymphocyte subset population of peripheral blood(CD3+

CD4+

CD8+

CD4+/CD8+) and natura killer(NK) were detected by flow cytometry. Result:The rate of relapse or migration in control group was 39.62%(21/53)

and in observation group was 17.64%(9/51)

and the rate of relapse or migration in the observation group was lower than the control group(P<0.05).Disease free survival in the control group was(19.7±6.9)mouths lower than the observation group(25.8±6.1)mouths(P<0.01).After 6 mouths of treatment

NK

CD3+

CD4+and CD4+/CD8+ in the observation group were higher than the control group

but CD8+ was lower than the control group(P<0.01).After 6 and 12 mouths of treatment

the improvement of QLQ-BR53 in the observation group were superior to the control group(P<0.01). Conclusion:Maintenance treatment of Fuzheng Xiaoji decoction can ameliorate patients' recent quality of life when it was used to patients after surgical treatment of breast cancer

it can prolong the time of relapse or migration and improve disease free survival of patients.