Objective: To investigate influence of surperfine grinding on stability of index components in compound Danshen powders under high temperature

high humidity and light conditions

respectively. Method: Compound Danshen powders with different particle sizes were prepared

taking comprehensive change rate of index components as index

after exposed them to high humidity

high temperature and light for five and ten days

HPLC was empolyed to determine content change of index components in compound Danshen powders with different particle sizes. Result: Under condition of high moisture

contents of cryptotanshinone and salvianolic acid B decreased much more among different compound Danshen powders

coarse powder decreased most

micropowder Ⅱ decreased least.High temperature had more obvious effect on tanshinone Ⅰ

tanshinol and salvianolic acid B

micropowder Ⅰ changed most

micropowder Ⅱ changed least.Light had most obvious effect on all index components

coarse powder changed most

micropowder Ⅱ changed least.Index components of Notoginseng Radix et Rhizoma from compound Danshen powders were stable after being exposed to high humidity

high temperature and light. Conclusion: Light had the greatest effect on index components in compound Danshen powders with different particle sizes

which showed that these powders should be stored away from light.With decreasing of particle size

stability of compound Danshen powders showed tendency of becoming better and then worse

micropowder Ⅱ had the most stable.