Objective: To investigate the intestinal absorption characteristics of alliin extract from garlic in the rabbit

and provide experimental data for pre-formulation study. Method: Using optical fiber sensing process analysis system combined with everted gut sac model and real-time and in situ determination of the concentration of alliin in the rabbit intestine

the absorption of different concentrations (70

50

30 mg·L-1)was observed in different bowels (n=6). Result: The absorption capacity of alliin in different bowels was as follows: jejunum> ileum > colon > duodenum; different concentrations of intestine jejunum absorption number An values were (2.59 ± 0.21

5.40 ± 0.11

3.81 ± 0.27); ileum were (5.25 ± 0.07

3.02 ± 0.19

4.09 ± 0.18) were greater than the value of An 1.15

duodenum were (0

0.95 ± 0.16

1.09 ± 0.28); colon were (0.50 ± 0.13

0.90 ± 0.22

1.08 ± 0.24) for each concentration An values were less than 1.15. Ke values for each concentration except duodenum (0

0.007 ± 0.22

0.004 ± 0.29) others are greater than 0.01 cm·min-1. Conclusion: Fiber Optic sensing system may used to determine the absorption of alliin(APIs) in the intestine in real-time

and the results show permeability of alliin in rabbit intestinal.