Objective: To study the therapeutic effect of Kangbai decoction on experimental vitiligo guinea pigs induced. Method: The experimental vitiligo guinea pig model was prepared by 5% hydroquinone. vitiligo capsule (0.24 g·kg-1) as control group

low

moderate and high dose (3.1

6.2

12.4 g·kg-1) of Kangbai decoction were orally given once a day for 50 days. The epidermal basal and prickle cell melanin distribution as well as the cholinesterase (CHE)

monoamine oxidase (MAO)

malondialdehyde (MDA) content were observed.The indexes of blood rheology

the content of tyrosinase and absorbance of melanin were measured. Result: After modeling

the whole blood viscosity and plasma viscosity and CHE

MAO and MDA of the model group were obviously increased. The melanin distribution and skin hair follicle melanin of skin epidermal basal and prickle cell

absorption of melanin and tyrosinase content were significantly decreased. Compared with the normal group (P<0.01). Kangbai decoction could significantly increased the melanin distribution and skin hair follicle melanin of skin epidermal basal and prickle cell(P<0.01). The absorption of melanin and tyrosinase content were increased.CHE

MAO and MDA content were decreased in the blood and improved the indexes of blood rheology obviously(P<0.01). Conclusion: Kangbai decoction had a good therapeutic effect on experimental vitiligo guinea pigs

and its main mechanisms may be related to promoting blood circulation

reducing blood CHE

MAO and MDA content and increasing the content of tyrosinase melanin

increasing the number of hair follicles and absorbance etc.