Objective: To study the effect of breviscapine on glucose and lipid metabolism in type 2 diabetes mellitus(T2DM) rats. Method: The T2DM model rats were induced by feeding of high-fat and high-carbohydrate diet and injecting streptozotocin and then were randomly divided into the model group(MG)

the low and high dose group(100

200 mg·kg-1·d-1

LG

HG)

A normal control group was also set up(NG). The drugs were given for 14 days by intraperitoneal injection. Then the general status

the fasting blood glucose (FBG)

insulin(INS)

blood lipid [total cholesterol(TC)

triglycerides(TG)

and low-density lipoprotein cholesterol(LDL-C)] and adiponectin(APN) levels were compared between each group. The rat pancreatic tissue pathological section were also made. Result: Compared with NG

there were obvious symptoms of diabetes in MG

levels of FBG

INS

TC

TG

LDL-C significantly increased and levels of APN decreased in MG(P<0.01).Compared with MG

the general status improved in both LG and HG

levels of FBG

INS

TC

TG

LDL-C significantly decreased and levels of APN increased in both LG and HG(P<0.01 or P<0.05). Conclusion: Breviscapine may adjust the disturbance in the glucose and lipid metabolism by improving the low adiponectin levels and insulin resistance in T2DM rats.