活血通痹散离子导入配合牵引疗法改善腰椎间盘突出症功能障碍的作用

钟秀莲; 牛淑芳; 王庆秧

doi:10.13422/j.cnki.syfjx.2014130205

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活血通痹散离子导入配合牵引疗法改善腰椎间盘突出症功能障碍的作用

临床 | 更新时间：2024-01-04

- 活血通痹散离子导入配合牵引疗法改善腰椎间盘突出症功能障碍的作用
- Huoxue Tongbi Powder Iontophoresis Combined with Traction Therapy on Prolapse of Lumbar Intervertebral Disc Disorder Effect
- 中国实验方剂学杂志 2014年20卷第13期页码：205-209
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- DOI：10.13422/j.cnki.syfjx.2014130205
  中图分类号： R274.9
- 纸质出版日期：2014
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钟秀莲, 牛淑芳, 王庆秧. 活血通痹散离子导入配合牵引疗法改善腰椎间盘突出症功能障碍的作用[J]. 中国实验方剂学杂志, 2014,20(13):205-209.

ZHONG Xiu-lian, NIU Shu-fang, WANG Qing-yang. Huoxue Tongbi Powder Iontophoresis Combined with Traction Therapy on Prolapse of Lumbar Intervertebral Disc Disorder Effect[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(13): 205-209.
钟秀莲, 牛淑芳, 王庆秧. 活血通痹散离子导入配合牵引疗法改善腰椎间盘突出症功能障碍的作用[J]. 中国实验方剂学杂志, 2014,20(13):205-209. DOI： 10.13422/j.cnki.syfjx.2014130205.

ZHONG Xiu-lian, NIU Shu-fang, WANG Qing-yang. Huoxue Tongbi Powder Iontophoresis Combined with Traction Therapy on Prolapse of Lumbar Intervertebral Disc Disorder Effect[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(13): 205-209. DOI： 10.13422/j.cnki.syfjx.2014130205.

摘要

目的：观察活血通痹散离子导入配合牵引疗法对腰椎间盘突出症（LDH）功能障碍改善作用及对白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）和β-内啡肽（β-EP）的影响。方法：将100例LDH患者随机按入院诊治顺序分成对照组和观察组各50例。对照组给予常规牵引治疗，1次/d；观察组在对照组治疗的基础上加用活血通痹散离子导入，1次/d。两组疗程均为28 d。采用疼痛视觉模拟评分（VAS）法记录治疗前、治疗后第7，14，21及28天患者疼痛情况；采用Oswestry 功能障碍指数对腰椎间盘突出症患者功能障碍进行评价，分别于治疗前、治疗后，治疗结束后3个月各进行1次评价；治疗前后对LDH各主要症状、体征进行评分；检测定治疗前后血浆β-内啡肽（β-EP）水平；检测治疗前后血清白细胞介素-1β（IL-1β）和肿瘤坏死因子-α（TNF-α）水平。结果：两组治疗后VAS评分持续下降，治疗后第7，14，21及28天观察组VAS评分均低于对照组（P<0.01）；经Ridit分析治疗后观察组疾病疗效优于对照组（P<0.05）；治疗后两组Oswestry 功能障碍指数均比治疗前下降（P<0.01）；治疗后观察组Oswestry 功能障碍指数低于对照组（P<0.01）；治疗结束后3个月两组Oswestry 功能障碍指数均有所上升（P<0.01），但观察组仍然低于对照组（P<0.01）；治疗后观察组腰腿疼痛、下肢麻木、向下肢放射及椎旁压痛评分均低于对照组（P<0.01）；两组治疗后血浆β-EP较治疗前上升，治疗后观察组β-EP水平高于对照组（P<0.01）；两组治疗后血清IL-1β及TNF-α水平均比治疗前下降，治疗后观察组IL-1β及TNF-α水平均低于对照组（P<0.01）。结论：活血通痹散离子导入配合牵引疗法能减轻LDH疼痛，改善患者症状、体征，促进患者功能的恢复。

Abstract

Objective: Observe amelioration of Huoxue Tongbi powder iontophoresis combined with traction therapy to dysfunction in treating lumbar disc herniation(LDH) and influence to interleukin-1β (IL-1β)

tumor necrosis factor-α(TNF-α) and β-endorphin(P-EP). Method: One hundred cases with LDH were randomly divided into control group (50 cases) and observation group (50 cases) according to the order of admission.Patients in control group received conventional traction therapy

1 time/day.Based on the therapy of control group

patients in observation group added iontophoresis of Huoxue Tongbi powder

1 time/day.Course of treatment in two groups were 28 days.Before treatment and at the seventh

fourteenth

twenty-first and the twenty-eighth day after treatment

patients conditions of pain were recorded by visual analogue scales(VAS)method.Before and after treatment and in the third mouth after finishing treatment

dysfunction of patients with LDH were evaluated by Oswestry dysfunction index.after treatment

the main symptom and sign of LDH were graded.Before and after treatment

the levels of β-endorphin in plasma

interleukin-1β (IL-1β) in serum and tumor necrosis factor-α(TNF-α) were detected. Result: After treatment both groups' scores of VAS continued decreasing

and at the seventh

fourteenth

twenty-first and twenty-eighth day

scores of VAS in observation group were lower than those in control group(P<0.01).Analyzed by Ridit

disease curative effect in observation group was superior to control group(P<0.05).Compared with the time before treatment

oswestry dysfunction index in two groups decreased(P<0.01)

and Oswestry dysfunction index in observation group was lower than the control group(P<0.01).Third month after finishing treatment

oswestry dysfunction index in two groups increased a little(P<0.01)

but Oswestry dysfunction index in observation group was still lower than the control group(P<0.01).Scores of lumbar and leg pain

numbness of lower limb

lower limb radiation pain and pressing pain in observation group were lower than those in control group(P<0.01). The two groups after treatment than before treatment increased plasma β -EP

after treatment the observation group of β-EP levels higher than the control grou (P<0.01).Level of IL-1β in serum and TNF-α in two groups decreased and the level of IL-1β in serum and TNF-α in observation group were lower than those in control group(P<0.01). Conclusion: Huoxue Tongbi powder iontophoresis combined with traction therapy can relief patients' pain with LDH

ameliorate patients' symptom and sign and promote patients' functions to recover.

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