Objective: To investigate the effect of therapy with modified Dachengqi decocotion combined with stilamir in severe acute pancreatitis (SAP). Method: Forty patients with SAP were randomly divided into two groups

the treated group treated with the combined therapy and the control group treated by stilamir alone. Serum amylase

calcium concentration

interleukin-6(IL-6)

IL-10

IL-18 and acute physiology and chronic health evaluation Ⅱ(APACHEⅡ) score were determined before and after treatment. And the incidence of complication and mortality were assessed. Result: The time of abdominal pain

distention disappearance

air charge recovering

and average hospitalization days in the treated group were significantly shorter than those in the control group respectively (P<0.05). Levels of serum amylase

IL-6

IL-18 and APACHEⅡscores were lower after treatment in both groups

level of serum calcium concentration were higher after treatment in both groups(P<0.05). Level of serum IL-10 were lowered after treatment in both groups

but it was higher at 10 days in the treated group again(P<0.05).The incidence of local complications in the treated group were significantly lower than those in the control group respectively (P<0.05).But the incidence of mortality between the two groups showed no statistical significance. Conclusion: Combined therapy of modified Dachengqi tang and stilamir is a recommended recipe in treatment of SAP

it could obviously improve the efficacy of treatment.