痰热清注射液治疗肺腺癌化疗后并发的肺部感染

马鸣; 邢亚威; 陈俊卓; 刘丽华; 杨兴肖; 单保恩

doi:10.13422/j.cnki.syfjx.2014130228

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痰热清注射液治疗肺腺癌化疗后并发的肺部感染

临床 | 更新时间：2024-01-04

- 痰热清注射液治疗肺腺癌化疗后并发的肺部感染
- Effect of Tanreqing Injection on Incurrening Infection after Chemotherapy in Lung Adenocarcinoma Patients
- 中国实验方剂学杂志 2014年20卷第13期页码：228-231
- 作者机构：
- 作者简介：
- 基金信息：
  
  河北省中医药管理局指令性课题项目（2013018）
- DOI：10.13422/j.cnki.syfjx.2014130228
  中图分类号： R734.2
- 纸质出版日期：2014
- 稿件说明：
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马鸣, 邢亚威, 陈俊卓, 等. 痰热清注射液治疗肺腺癌化疗后并发的肺部感染[J]. 中国实验方剂学杂志, 2014,20(13):228-231.

MA Ming, XING Ya-wei, CHEN Jun-zhuo, et al. Effect of Tanreqing Injection on Incurrening Infection after Chemotherapy in Lung Adenocarcinoma Patients[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(13): 228-231.
马鸣, 邢亚威, 陈俊卓, 等. 痰热清注射液治疗肺腺癌化疗后并发的肺部感染[J]. 中国实验方剂学杂志, 2014,20(13):228-231. DOI： 10.13422/j.cnki.syfjx.2014130228.

MA Ming, XING Ya-wei, CHEN Jun-zhuo, et al. Effect of Tanreqing Injection on Incurrening Infection after Chemotherapy in Lung Adenocarcinoma Patients[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(13): 228-231. DOI： 10.13422/j.cnki.syfjx.2014130228.

摘要

目的：观察痰热清注射液对肺腺癌化疗后并发肺部感染患者的疗效及其对患者机体免疫功能的影响。方法：临床选取肺腺癌化疗后并发肺部感染患者70例，其中35例为痰热清治疗组，应用痰热清注射液联合抗生素治疗；35例为对照组，单纯注射抗生素治疗。分别对两组病人进行临床观察，并进行相关实验室检查。同时，在用药前后，通过流式细胞术检测患者的外周血T淋巴细胞亚群，并通过银染色法检测患者淋巴细胞中核仁形成区嗜银蛋白含量（AgNORs）的相对含量（I.S）。ELISA法检测患者血清中转化生长因子-β1（TGF-β1）的含量。结果：痰热清治疗组疗效明显优于对照组（P<0.05），且患者外周血T细胞亚群、TGF-β1含量及淋巴细胞I.S值较对照组改善更为明显（P<0.05）。结论：痰热清注射液联合抗生素治疗肺腺癌化疗后并发肺部感染较单独使用抗生素更为有效，同时该药还对患者具有一定的免疫调节作用。

Abstract

Objective: To investigate the effects of herbal Tanreqing injection on infection and the immunoregulation function in lung adenocarcinoma patients of after chemotherapy. Method: Seventy lung adenocarcinoma cases suffered from incurrenting infectious pneumonia after chemotherapy were divided into 2 groups:control group treated by

test group antibiotics

test group

treated by Tanreqing-injection combined with antibiotics. The clinical symptoms were observed

and the peripheral blood T lymphocytes were detected their before or after administration by flow cytometry(FCM).The ordinary silver staining technology was was used used to measure the relative content(I . S) of argyrophil nucleolar organizer region(AgNORs) in lymphocytes

and level of transforming growth factor(TGF-β1) in the serum was detected by ELISA. Result: Therapeutic effects of treat group were better than control group (P<0.05). Meanwhile

improvement situations in peripheral-blood T lymphocytes subset

TGF-β1 content and I . S value of Tanreqing injection treated group group were more notable than control group (P<0.05). Conclusion: Herbal Tanreqing injection with antibiotics is more effective than antibiotics. Meanwhile

it also displayed certain immunoregulation functionsonia.

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