Objective: To optimize formulation of Fangbing nasal inhalants. Method: With sleep duration and sleep latency of rats as comprehensive evaluation indexes

L9 (34) orthogonal test was performed to optimize prescription by taking amounts of menthol

linalool and borneol as factors.Considering and measuring solubility of menthol and borneol

odor of nasal inhalants

single factor test was adopted to investigate effect of ethanol concentration on release of Fangbing nasal inhalants;taking in vitro release of menthol

linalool and borneol as indexes

combined with efficacy test of sleep deprivation to determine optimum formulation of this preparation. Result: Optimum formulation was as following:borneol 0.15 g

linalool 0.4 mL

menthol 0.070 9 g

90% ethanol 0.1 mL;under these conditions

incubation period and sleep duration were (13.26±1.51)

(43.58±1.94) min. Conclusion: This optimized formulation was reasonable with flavor of aromatic and pleasing

it could provide a references for development of pulmonary drug delivery of traditional Chinese medicine.