This paper briefly introduced main factors of adverse reactions caused by Chinese patent medicine

including drug toxicity

confusable species

improper processing

inappropriate drug dosage

incorrect compatibility and individual difference of patients.Through searching literatures

this article summarized different techniques used in traditional Chinese medicine(TCM) preparation industry

then analysed effects of modern preparation technology on drug safety and adverse reactions.Compared with traditional process

modern preparation technology may change chemical composition of TCM preparation

drug dosage

drug formulation

drug delivery or add processing impurity

which could make passive effect on drug safety.This paper also proposed effective solutions for drug safety and appealed that we should strengthen research on basic chemical constituents of TCM

toxicology of TCM

correlation between preparation process and clinical application

establishment quality control system of pharmaceutical excipients to improve its safety

and improvement of significance participation degree of enterprises in adverse reactions monitoring system

in order to provide a reference for clinical rational drug use of preparations of TCM.