Objective: To study the effect of Majiang Xuanfei capsule on antitussive

expectorant

anti-inflammatory

antipyretic and antiasthmatic activities. Method: Mice were randomly divided into 5 groups:normal control group

positive group

Majiang Xuanfei capsule high dose

middle dose and low dose groups(2.49

1.24

0.62 g·kg-1). After 7 days of ig administration

aqueous ammonia

phenol red

mouse ear swelling

expectorant were used to study the dosage-effect relation of Majiang Xuanfei capsule in mice. Rats were randomly divided into blank group

positive medicine group

model group and Majiang Xuanfei capsule high

medium and low dose groups (1.8

0.9

0.45 g·kg-1). The antipyretic activity of Majiang Xuanfei capsule was observed by endotoxin in rats. Guinea pigs were randomly divided into blank group

positive medicine group and Majiang Xuanfei capsule high

medium and low dose groups (1.55

0.77

0.39 g·kg-1). The antiasthma effect of Majiang Xuanfei capsule was studied by the asthma time induced by acetylcholine chloride and histamine phosphate in guinea pigs. Result: Majiang Xuanfei capsule could reduce the frequency of cough induced by ammonia and prolong the latent period of cough (P<0.05

P<0.01). High dose could increase the phenol red excretion of respiratory tract in mice (P<0.01).High

medium and low dose could inhibit the mouse ear swelling induced by xylene (P<0.05). High dose could inhibit the temperature in rats induced by fat polysaccharide (P<0.05

P<0.01) and prolong the asthma time induced by acetylcholine chloride and histamine phosphate in guinea pigs (P<0.05

P<0.01). Conclusion: Majiang Xuanfei capsule has antitussive

expectorant

anti-inflammatory

antipyretic

and antiasthmatic activities.