Objective: To evaluate the clinical efficacy and safety of Xingnaojing injection for acute cerebral hemorrhage

and explore its possible molecular mechanisms of pharmacological action. Method: One hundred and ten cases of acute cerebral hemorrhage were randomized into 2 groups by random number table method

including Xingnaojing treatment group and routine treatment group

with 55 cases in each group. The routine treatment group was given regular treatment with ICP-lowering

neurotrophic drug treatment and symptomatic treatment. On the basis of regular treatment

Xingnaojing treatment group was given Xingnaojing injection

as an adjuvant therapy

via intravenous infusion at a dose of 30 mL daily for seven days. Glasgow coma score (GCS) and the national institutes of health stroke scale (NIHSS) were performed to evaluate the states of consciousness and neural function before treatment and after treatment for 1

3 and 7 days. Venous bloods of patients were collected for detecting the levels of high-sensitivity C-reactive protein(hs-CRP)and neuron specific enolase(NSE)in the serum at the different time points mentioned above. Immunoturbidimetry was applied for detecting the level of hs-CRP

and the ELISA was employed to analysis the content of NSE. Moreover

clinical symptoms

vital signs

routine blood and urine tests

as well as hepatic and renal function were observed before and after IV infusion of Xingnaojing. Result: Compared with routine treatment group

significant improvements of GCS score and NIHSS score were evident in patients treated with Xingnaojing injection for 7 days (P<0.05)

the levels of hs-CRP in the serum were decreased remarkably after treatment for 3 days and 7 days(P<0.05)

and the content of NSE in the serum from sub-group that treated with Xingnaojing injection for 7 days was significantly lower than that in control group as well. However

Xingnaojing injection did not change liver and kidney function indices after treatment for 7 days

and no adverse event occurred during the treatment with Xingnaojing injection. Conclusion: Xingnaojing injection exerted obvious therapeutic effects on acute cerebral hemorrhage with no servere adverse effects

and suppressing inflammatory response and alleviating neuronal damage may serve as an important pharmacological action mechanism.