Objective: Observe regulating effect of Shugan Jianpi decoction to patients' glucose metabolism and lipid metabolism in treating early-stage diabetes and influence to inflammatory factor. Method: Ninety-one patients with early-stage diabetes were randomly divided into control group (45 cases) and observation group (46 cases)according to registration order.Patients in control group received pioglitazone hydrochloride and metformin hydrochloride tablets

1 tablet/time

2 times/day

taken orally.Patients in observation group received Shugan Jianpi decoction

1 dose/day.Course of treatment in two groups were both 12 weeks.After treatment

patients' weight and waist were measured.and levels of blood lipid was detected which including triglyceride(TG)

total cholesterol(TC)

high-density lipoprotein(HDL-C) and low density lipoprotein(LDL-C).Before and after treatment

fasting blood-glucose(FBG)

fasting insulin(FINS)

2 hours postprandial blood glucose(2 hPG) and glycosylated hemoglobin(HbAlc) were detected.body mass index(BMI)

homeostasis model assessment-insulin resistance index(HOMA-IR) of insulin

homeostasis model assessment-insulin secretion of pancreatic β-cell and insulin sensitivity index(ISI) were detected.and levels of adiponectin(APN)

interleukin-6(IL-6) and high-sensitivity c-reactive protein(hs-CRP) were also detected. Result: After treatment

compared with the time before treatment

waist and BMI in two groups decreased

which means no statistical significance from the differences between two groups

and there was a decreasing tendency of patients' weight.Levels of FBG

2 hPG

HbA1c and FINS in observation group were lower than those in control group(P<0.05 or P<0.01).HOMA-IR in observation group was lower than in control group(P<0.01) and HOMA-IS and ISI were higher than those in control group(P<0.01).Cases of turning normal of TC

TG

LDL-C and HDL-C in observation group were more than those in control group(P<0.01).Serous APN in observation group was higher than in control group(P<0.01)

and levels of IL-6 and hs-CRP in observation group were lower than those in control group(P<0.01). Conclusion: Shugan Jianpi decoction can regulate patients' glucose metabolism and lipid metabolism in treating early-stage diabetes

and prolong or reversion speed of early-stage diabetes turning into diabetes

its mechanism of action may be related to regulating APN

IL-6 and hs-CRP and reducing chronic inflammatory reaction.