Objective: To optimize extraction technology of total flavonoids in roots of Petroselinum crispum and screen type of macroporous resin which appropriated to its enrichment and purification. Method: UV was adopted to determine the content of total flavonoids with detection wavelength at 510 nm.With composite score of yields of total flavonoids and extract as index

orthogonal test was used to optimize extraction process by taking ethanol concentration

ratio of solid to liquid

extracting time and times as factors;the best type of macroporous resin was selected by static adsorption-elution test. Result: Optimum extraction process was as following:extracted twice with six times the amount of 70% ethanol for one hour per time;yields of total flavonoids and extract were 0.75% and 14%

respectively.D101 macroporous resin was the best one for purifying total flavonoids in roots of P. crispum. Conclusion: This optimized technology was stable and feasible

this screened resin had good separation and purification effect

this study could provide a reference for drug developmeng of roots of P. crispum.