Objective: To observe clinical efficacy of Shufeng Jiejing decoctions and influence to serous total immunoglobulin E(IgE)

eosnophils(EOS)

and asthmatics cellular factors in treating childhood cough variant asthma(CVA). Method: Ninety patients were randomly divided into control group(45 cases) and observation group(45 cases) by digital method

and establish healthy control group(15 cases).Patients in the control group took montelukast sodium chewable tablets with 4-5 years old for 4 mg and 6-12 years old for 5 mg

took before sleep.Patients in the observation group added Shufeng Jiejing decoctions based on the treatment of the control group

1 does/day.Course of treatment in two groups were both four weeks.Main symptom scores of cough frequency

cough degree

cough nature

et al before and after treatment were recorded.

levels of serum total IgE

peripheral blood EOS

tumor necrosis factor-α(TNF-α)

interleukin-4(IL-4)

interleukin-10(IL-10) and interferon-γ(IFN-γ) before and after treatment were detected. Result: Total effective rate of curative efficacy in the observation group was 93.33% superior to 77.78% in the control group(P<0.05). After treatment

grades of main symptoms of cough frequency

cough degree

cough nature

tchypne and pharyngeal itching in the observation group were lower than those in the control group(P<0.01)

levels of serous total IgE

TNF-α

IL-4 and EOS in the observation group were lower than those in the control group(P<0.01)

but levels of IL-10 and IFN-γ were higher than those in the control group(P<0.01). Conclusion: Differentiation treatment of Shufeng Jiejing decoctions could ameliorate symptoms and improve curative efficacy in treating childhood cough variant asthma

and it could regulate levels of cytokines and reduce airway hyperresponsiveness.