大黄素soluplus聚合物胶束的制备及质量评价

典灵辉; 于恩江; 程纪伦; 郭向华; 黄紫荣; 张振声

doi:10.13422/j.cnki.syfjx.2014160015

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大黄素soluplus聚合物胶束的制备及质量评价

工艺与制剂 | 更新时间：2024-01-04

- 大黄素soluplus聚合物胶束的制备及质量评价
- Preparation and Quality Evaluation of Emodin-loaded Soluplus Polymeric Micelles
- 中国实验方剂学杂志 2014年20卷第16期页码：15-18
- 作者机构：
- 作者简介：
- 基金信息：
  
  广东省建设中医药强省项目（20131261）;广东省卫生厅项目（A2013427）;东莞市国际合作项目（20135081520012）
- DOI：10.13422/j.cnki.syfjx.2014160015
  中图分类号： R283.6
- 纸质出版日期：2014
- 稿件说明：
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典灵辉, 于恩江, 程纪伦, 等. 大黄素soluplus聚合物胶束的制备及质量评价[J]. 中国实验方剂学杂志, 2014,20(16):15-18.

DIAN Ling-hui, YU En-jiang, CHENG Ji-lun, et al. Preparation and Quality Evaluation of Emodin-loaded Soluplus Polymeric Micelles[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(16): 15-18.
典灵辉, 于恩江, 程纪伦, 等. 大黄素soluplus聚合物胶束的制备及质量评价[J]. 中国实验方剂学杂志, 2014,20(16):15-18. DOI： 10.13422/j.cnki.syfjx.2014160015.

DIAN Ling-hui, YU En-jiang, CHENG Ji-lun, et al. Preparation and Quality Evaluation of Emodin-loaded Soluplus Polymeric Micelles[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(16): 15-18. DOI： 10.13422/j.cnki.syfjx.2014160015.

摘要

目的：制备大黄素的soluplus聚合物胶束并对其进行质量评价。方法：采用薄膜分散法制备大黄素聚合物胶束（Emo-PMs）。利用粒径测定仪、透射电镜、X-射线衍射对其进行表征；采用HPLC测定Emo-PMs的包封率和载药量，流动相甲醇-0.1% 磷酸（75：25），检测波长437 nm；采用动态膜透析法考察载药胶束的体外释药特性。结果： Emo-PMs呈球形或类球形，平均粒径（65±3.8）nm，多分散系数0.099±0.022，Zeta电位-（12.7±0.19）mV，平均包封率（88.25±3.51）%，平均载药量（4.51±0.72）%；大黄素以无定形状态或分子状态包载在聚合物胶束中；Emo-PMs具有缓释作用，释放机制符合Higuchi方程。结论：制备的Emo-PMs粒径、包封率、载药量可控，具有缓释作用。

Abstract

Objective: To prepare emodin-loaded soluplus polymeric micelles (Emo-PMs) and evaluate their quality. Method: Emo-PMs were prepared by film dispersion method using an amphiphilic copolymer soluplus.Emo-PMs were characterized by particle size analyzer

transmission electron microscopy (TEM)

X-ray diffraction (XRD);release curve was determined by dynamic membrane dialysis;HPLC was employed to determine entrapment efficiency and drug loading with mobile phase of methanol-0.1% phosphoric acid(75:25) and detection wavelength ar 437 nm. Result: Emo-PMs showed spherical with a mean particle size of (65±3.8)nm

polydispersity index of 0.099±0.022

Zeta potential of-(12.7±0.19) mV

average encapsulation efficiency of (88.25±3.51)% and average drug loading of (4.51±0.72)%.Emodin entrapped in polymer micelles with amorphous or molecular form;release methanism of Emo-PMs fitted Higuchi equation. Conclusion: These prepared Emo-PMs had exhibited in vitro sustained release

their particle size

encapsulation efficiency and drug loading were controllable.

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